Oleanolic acid and related derivatives as medicinally important compounds

PCSIR Laboratories Complex, Pharmaceutical Research Center, Karachi, Pakistan.
Journal of Enzyme Inhibition and Medicinal Chemistry (Impact Factor: 2.38). 08/2008; 23(6):739-56. DOI: 10.1080/14756360701633187
Source: PubMed

ABSTRACT Oleanolic acid has been isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids. The literature survey revealed it to be biologically very important. In this review the biological significance of oleanolic acid and its derivatives has been discussed. The aim of this review is to update current knowledge on oleanolic acid and its natural and semisynthetic analogs, focussing on its cytotoxic, antitumer, antioxidant, anti-inflamatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic, spasmolytic activity, anti-angiogenic, antiallergic, antiviral and immunomodulatory activities. We present in this review, for the first time, a compilation of the most relevant scientific papers and technical reports of the chemical, pre-clinical and clinical research on the properties of oleanolic acid and its derivatives.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Pentacyclic triterpenes are natural substances, synthesized and present in variable amounts in a large number of terrestrial and aquatic plants, acting as antioxidants and antimicrobials, and also as poisons, antibiotics, protease inhibitors, and so on. From the organic chemical point of view, they are compounds derived from isoprene. These are compounds consisting of 30 carbons presenting different substituents which facilitate chemical identification and also confer different physicochemical and molecular properties. During the last ten years, most of them have been described as having a huge variety of interesting and significant biological properties, such as analgesic, anti-allodynic, anti-diabetic, anti-oxidant, anti-parasitic, anti-microbial, anti-viral, anti-atherogenic, anti-inflammatory, anti-proliferative, anti-tumour, growth-stimulating activities as well as cardio- and neuro-protective activity. However, special attention has been focused on the study of their anti-tumour capacity, focused fundamentally on the various molecular mechanisms involved in the induction of programmed cell death and the inhibition of metastatic activity, in accordance with different types of cancers. Researchers have also focused on the role that different RNA molecules play in the anti-tumour activity of the major triterpenes studied. The purpose of this paper is to review the recent advances described for the main representatives of this group of compounds, such as betulinic (BA), ursolic (UA), oleanolic (OA) and maslinic (MA) acids and some of their derivatives, and on their anti-tumourigenic role, with special emphasis on cell apoptosis and angiogenesis.
    Current Organic Chemistry 05/2015; 19(10):919-947. DOI:10.2174/1385272819666150119225952 · 2.54 Impact Factor
  • Source
    International Journal of Pharmacy and Pharmaceutical Sciences 01/2015; · 1.59 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Aim of the Review. To grasp the fragmented information available on the botany, traditional uses, phytochemistry, pharmacology, and toxicology of Olea europaea to explore its therapeutic potential and future research opportunities. Material and Methods. All the available information on O. europaea was collected via electronic search (using Pubmed, Scirus, Google Scholar, and Web of Science) and a library search. Results. Ethnomedical uses of O. europaea are recorded throughout the world where it has been used to treat various ailments. Phytochemical research had led to the isolation of flavonoids, secoiridoids, iridoids, flavanones, biophenols, triterpenes, benzoic acid derivatives, isochromans, and other classes of secondary metabolites from O. europaea. The plant materials and isolated components have shown a wide spectrum of in vitro and in vivo pharmacological activities like antidiabetic, anticonvulsant, antioxidant, anti-inflammatory, immunomodulatory, analgesic, antimicrobial, antiviral, antihypertensive, anticancer, antihyperglycemic, antinociceptive, gastroprotective, and wound healing activities. Conclusions. O. europaea emerged as a good source of traditional medicine for the treatment of various ailments. The outcomes of phytochemical and pharmacological studies reported in this review will further expand its existing therapeutic potential and provide a convincing support to its future clinical use in modern medicine.
    Evidence-based Complementary and Alternative Medicine 01/2015; 2015:541591. DOI:10.1155/2015/541591 · 2.18 Impact Factor