Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction

Harvard University, Cambridge, Massachusetts, United States
Psychosomatics (Impact Factor: 1.67). 07/2008; 49(4):309-16. DOI: 10.1176/appi.psy.49.4.309
Source: PubMed

ABSTRACT Depression (MDD) and anxiety have been associated with negative long-term outcomes among patients with acute myocardial infarction (MI).
The objective of the study was to determine whether MDD and anxiety preceding MI were associated with in-hospital post-MI cardiac complications.
Subjects (N=129) underwent psychiatric interviews within 72 hours of MI and were evaluated for five in-hospital cardiac complications (recurrent ischemia, ventricular arrhythmia, ventricular arrhythmia requiring intervention, congestive heart failure, and reinfarction).
Current (pre-MI) MDD was a significant and independent predictor of all complications except recurrent ischemia on multivariate regression analysis. In contrast, pre-MI anxiety was not associated with complications.
These findings underscore the importance of identifying and treating MDD in post-MI patients and those at risk for MI.

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