Ectomesenchymal chondromyxoid tumor of the anterior aspect of the tongue
ABSTRACT Ectomesenchymal chondromyxoid tumor of the anterior aspect of the tongue is a benign rare tumor. Thirty cases have been reported so far. It presents as a slowly growing, asymptomatic, submucosal nodule on the anterior dorsum of the tongue. Histopathologically, the tumor is composed of a well-circumscribed, lobular proliferation of fusiform and ovoid cells in a chondromyxoid background. Most consistent immunohistochemical finding is the diffuse and strong immunoreactivity for glial fibrillary acid protein. Histogenetic origin of the tumor is uncertain. We report here a 56-year-old woman with a 0.7-cm tumoral lesion of 5 months' duration on the anterior aspect of her tongue. Total excision was performed and histopathologic findings were consistent with ectomesenchymal chondromyxoid tumor. No recurrence was observed after 2 years of follow-up.
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ABSTRACT: Ectomesenchymal chondromyxoid tumors (ECT) are rare, benign, intraoral mesenchymal soft tissue tumors that can be diagnostically challenging. In this study the demographic, clinical, histopathologic, and immuno-histochemical features of seven ECTs are examined. The differential diagnosis of this rare neoplasm is discussed and the literature is reviewed.Head and Neck Pathology 11/2014; DOI:10.1007/s12105-014-0578-9
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ABSTRACT: Zusammenfassung Der ektomesenchymale chondromyxoide Tumor des vorderen Zungenabschnitts ist eine sehr seltene Entität. Insgesamt wurden in der Literatur 37 Fälle mitgeteilt. Wir stellen einen 52-jährigen Mann mit einem ektomesenchymalen chondromyxoiden Tumor an typischer Lokalisation mit charakteristischer lobulärer Proliferation monomorpher Tumorzellen in einem chondromyxoiden Stroma sowie Expression der typischen immunhistochemischen Marker GFAP und S-100 vor. Trotz seiner Seltenheit sollte dieser spezielle Tumor bei umschriebenen Schwellungen des vorderen Zungenabschnitts in der Differenzialdiagnose berücksichtigt werden.Der Pathologe 11/2011; DOI:10.1007/s00292-011-1454-y · 0.64 Impact Factor
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ABSTRACT: The objective of this study was to investigate the histogenesis of ectomesenchymal chondromyxoid tumors (ECTs) of the tongue. The biochemical characteristics of a rarely occurring tumor of the tongue were analyzed by immunohistochemistry and reverse-transcriptase polymerase chain reaction (RT-PCR), and its biological properties were assessed in primary culture in serum-free media. Immunohistochemistry showed that the tumor cells were strongly positive for vimentin, S-100, and glial fibrillary acidic protein (GFAP), but negative for cytokeratin and epithelial membrane antigen. In primary cultures, the cells derived from the ECT were morphologically similar to neuronal cells and expressed Nanog, GFAP, and MAP2. RT-PCR analysis of the surgical specimen was positive for OCT3/4, Sox2, Nanog, MAP2, and CD105 mRNAs. The results of the present study indicate that ECTs originate from the ectomesenchymal cells of the neural crest and are similar in their molecular and biological characteristics to undifferentiated mesenchymal stem cells.02/2013; 115(2):233-40. DOI:10.1016/j.oooo.2012.11.008