Article

Disulfide-containing cross-linked PEI derivative synthesized by click chemistry for non-viral gene delivery.

Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, China.
Journal of Controlled Release (impact factor: 5.73). 11/2011; 152 Suppl 1:e157-9. DOI:10.1016/j.jconrel.2011.08.060 pp.e157-9
Source: PubMed

ABSTRACT Novel reducible disulfide-containing cross-linked polyethylenimines (PEI-SS-CLs) with high molecular weight (M(W)) were synthesized by click chemistry between disulfide-containing dialkyne cross-linkers and the azide functionalized low M(W) PEIs and evaluated as gene carriers. In vitro experiments revealed that the reducible PEI-SS-CLs were less cytotoxic and more effective in the gene transfection (both in the presence and absence of serum) than branched PEI (25kDa). These polymers are therefore attractive candidates for further in vivo evaluations.

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Keywords

branched PEI
 
disulfide-containing dialkyne cross-linkers
 
gene carriers
 
gene transfection
 
Novel reducible disulfide-containing cross-linked polyethylenimines
 
PEI-SS-CLs
 
reducible PEI-SS-CLs
 
vitro experiments
 
vivo evaluations