Article

Utility of co-transplanting mesenchymal stem cells in islet transplantation.

Naoaki Sakata, Gumpei Yoshimatsu, Shinichi Egawa, Michiaki Unno, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
World Journal of Gastroenterology (impact factor: 2.47). 12/2011; 17(47):5150-5. DOI:10.3748/wjg.v17.i47.5150 pp.5150-5
Source: PubMed

ABSTRACT Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. The mechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.

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Keywords

angiogenesis
 
animal studies
 
beneficial impact
 
co-transplantation
 
diabetic recipient
 
donor pancreata
 
insulin dependent diabetes mellitus
 
islet function
 
Islet transplantation
 
islets
 
MSCs
 
MSCs co-transplantation
 
transplantation
 
viable choice