Article

Prevalence of human papillomavirus in breast cancer: a systematic review.

Laboratory of Epidemiology and National Institute for Translational Medicine Health Sciences Unit, University of Extremo Sul Catarinense (UNESC), Criciúma, Santa Catarina.
International Journal of Gynecological Cancer (impact factor: 1.65). 12/2011; 22(3):343-7. DOI:10.1097/IGC.0b013e31823c712e pp.343-7
Source: PubMed

ABSTRACT We performed a systematic review and meta-analyses to estimate the prevalence of human papillomavirus (HPV) in breast carcinoma and to explore the reasons for the ongoing controversies about this issue.
A comprehensive search of the Cochrane Library, MEDLINE, CANCERLIT, LILACS, and EMBASE databases was performed for papers published from January 1990 to January 2011. The medical subject heading terms were searched for the following: breast neoplasm, breast lesions, breast cancer, and HPV or human papillomavirus. Statistical analysis was performed using REVMAN 5.0.
Twenty-nine primary studies, including 2211 samples, were analyzed. Overall, HPV prevalence in patients with breast cancer was 23.0% (95% CI, 21.2%-24.8%). The prevalence of HPV ranged from 13.4% (95% CI, 10.2%-16%) in Europe to 42.9% (95% CI, 36.4%-49.4%) in North America and Australia. The prevalence of HPV in controls was 12.9%. Combinations of 9 case-control studies showed that breast cancer was associated with HPV (odds ratio, 5.9; 95% CI, 3.26-10.67).
We found a high prevalence of HPV DNA in breast cancer. There is strong evidence to suggest that HPV has an important role in the development of breast cancer.

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    Article: Breast cancer and human papillomavirus infection: no evidence of HPV etiology of breast cancer in Indian women.
    Suresh Hedau, Umesh Kumar, Showket Hussain, Shirish Shukla, Shailja Pande, Neeraj Jain, Abhishek Tyagi, Trivikram Deshpande, Dilafroze Bhat, Mohammad Muzaffar Mir, Sekhar Chakraborty, Y Mohan Singh, Rakesh Kumar, Kumaravel Somasundaram, Alok C Bharti, Bhudev C Das
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    ABSTRACT: Two clinically relevant high-risk HPV (HR-HPV) types 16 and 18 are etiologically associated with the development of cervical carcinoma and are also reported to be present in many other carcinomas in extra-genital organ sites. Presence of HPV has been reported in breast carcinoma which is the second most common cancer in India and is showing a fast rising trend in urban population. The two early genes E6 and E7 of HPV type 16 have been shown to immortalize breast epithelial cells in vitro, but the role of HPV infection in breast carcinogenesis is highly controversial. Present study has therefore been undertaken to analyze the prevalence of HPV infection in both breast cancer tissues and blood samples from a large number of Indian women with breast cancer from different geographic regions. The presence of all mucosal HPVs and the most common high-risk HPV types 16 and 18 DNA was detected by two different PCR methods - (i) conventional PCR assays using consensus primers (MY09/11, or GP5+/GP6+) or HPV16 E6/E7 primers and (ii) highly sensitive Real-Time PCR. A total of 228 biopsies and corresponding 142 blood samples collected prospectively from 252 patients from four different regions of India with significant socio-cultural, ethnic and demographic variations were tested. All biopsies and blood samples of breast cancer patients tested by PCR methods did not show positivity for HPV DNA sequences in conventional PCRs either by MY09/11 or by GP5+/GP6+/HPV16 E6/E7 primers. Further testing of these samples by real time PCR also failed to detect HPV DNA sequences. Lack of detection of HPV DNA either in the tumor or in the blood DNA of breast cancer patients by both conventional and real time PCR does not support a role of genital HPV in the pathogenesis of breast cancer in Indian women.
    BMC Cancer 01/2011; 11:27. · 3.01 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

9 case-control studies
 
breast cancer
 
breast carcinoma
 
breast lesions
 
breast neoplasm
 
CANCERLIT
 
Cochrane Library
 
comprehensive search
 
EMBASE databases
 
HPV
 
HPV DNA
 
HPV prevalence
 
human papillomavirus
 
medical subject
 
North America
 
odds ratio
 
prevalence
 
primary studies
 
reasons
 
systematic review