Extraneural Metastasis of a Nongerminomatous Germ Cell Tumor of the Central Nervous System in a Pediatric Patient With a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature

Medical College of Wisconsin, Pediatric Oncology, Milwaukee, WI 53226, USA.
Journal of Pediatric Hematology/Oncology (Impact Factor: 0.9). 01/2012; 34(1):e12-6. DOI: 10.1097/MPH.0b013e31823dd370
Source: PubMed


We describe the case of a 7-year-old white boy who presented with a mixed malignant germ cell tumor with predominant embryonal carcinoma component. The patient underwent right ventriculoperitoneal (VP) shunt placement for hydrocephalus at the time of diagnosis. He received multiagent chemotherapy followed by second-look surgery. Despite an initial response to chemotherapy, the patient had metastatic progression of disease within the craniospinal axis. He received craniospinal radiation and high-dose chemotherapy. Although, he had resolution of central nervous system (CNS) disease, follow-up off treatment revealed extra-abdominal metastases. This is a rare case to discuss abdominal metastasis of a CNS germ cell tumor in a patient with a VP shunt. The influence of VP shunt placement on treatment and management decisions of patients with CNS tumors will be discussed.

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