Article

Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria japonica.

Department of Biology, Kyushu University, Fukuoka 812-8581, Japan.
Genetics (impact factor: 4.01). 12/2011; 190(3):1145-8. DOI:10.1534/genetics.111.136697 pp.1145-8
Source: PubMed

ABSTRACT We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55 × 10(-5) and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.

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Keywords

base pair
 
Cryptomeria japonica
 
Cupressaceae
 
decay
 
large part
 
linkage disequilibrium
 
population recombination rate
 

Etsuko Moritsuka