Article

Emerging cellular networks for regulation of T follicular helper cells.

Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.
Trends in Immunology (impact factor: 10.4). 12/2011; 33(2):59-65. DOI:10.1016/j.it.2011.11.006 pp.59-65
Source: PubMed

ABSTRACT The cellular networks that regulate humoral immune responses have been a focus of research over the past three decades. Studies have shown that inhibition of immune responses can be attributed to both suppressor T cells and B cells. More recently, T follicular helper (Tfh) cells have been identified as a target of immune regulation. Tfh cells are a subset of highly activated T helper cells specialized for providing cognate help to B cells during germinal center reactions. In this review, we describe emerging evidence for cellular networks that alter Tfh cell phenotype and function and regulate antibody production during the germinal center reaction. We discuss how these new findings influence our understanding of Tfh cells.

0 0
 · 
0 Bookmarks
 · 
53 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

activated T helper cells specialized
 
alter Tfh cell phenotype
 
B cells
 
cellular networks
 
germinal center reaction
 
germinal center reactions
 
immune regulation
 
inhibition
 
regulate humoral immune responses
 
suppressor T cells
 
T follicular helper
 
Tfh
 
Tfh cells
 
three decades