Reproducibility of Macular Thickness Measurement Among Five OCT Instruments: Effects of Image Resolution, Image Registration, and Eye Tracking
ABSTRACT To study the effect of image resolution, eye tracking, and image registration on central macular thickness reproducibility (rCMT) among spectral-domain and time-domain optical coherence tomography (SD-OCT and TD-OCT) instruments.
Seventy-six eyes were imaged (44 normal, 32 maculopathy) either twice using four SD-OCT and one TD-OCT devices or three times using Spectralis SD-OCT (with and without eye tracking) (Heidelberg Engineering, Inc., Heidelberg, Germany). Cirrus images (Carl Zeiss Meditec, Dublin, CA) were further analyzed with three-point image registration.
All instruments had superior rCMT in normal versus pathologic eyes (P < .001). No difference in rCMT was noted among instruments in normal eyes (P = .92), but TD-OCT was superior to SD-OCT (P = .017) in pathologic eyes. Cirrus image registration improved rCMT for normal eyes (P = .04), with borderline improvement in pathologic eyes (P = .06). Spectralis eye tracking improved rCMT in normal (P = .01) and pathologic (P = .004) eyes.
Higher image resolution with SD-OCT may not improve rCMT, but image registration and eye tracking options may improve rCMT.
- [Show abstract] [Hide abstract]
ABSTRACT: Optical coherence tomography (OCT) is a noninvasive, noncontact imaging technique capable of producing high-resolution images of the retina and optic nerve. These images provide information that is useful for following the progression and/or resolution of posterior segment disease. Rapid advances in OCT technology allow the acquisition of increasingly detailed images, approaching the original goal of providing in vivo histopathology. Increases in scan acquisition speeds and axial resolution enhance the clinical diagnostic value of this modality. Adapting instrumentation designed for use in human patients for use in animals can be challenging. Each species has a unique set of adjustments that need to be made but it is possible to obtain reproducible, high-quality OCT images in a variety of animals, including rodents, dogs, cats, pigs, and monkeys. Deriving quantitative measurements from OCT instruments is hindered by software algorithm errors in detecting the edges of the distinct retinal layers. These segmentation errors occur in scans of human eyes as well in other species and arise with similar frequency with each of the different OCT instruments. Manual segmentation methods to derive optic nerve head and other structural indices have been developed for several species.Veterinary Ophthalmology 07/2012; 15 Suppl 2:13-28. DOI:10.1111/j.1463-5224.2012.01045.x · 1.09 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The clinical vision examination routinely includes an evaluation of ocular motor function. In a number of diverse situations, thorough objective recording of eye movements is warranted, using any of a variety of eye-tracking technologies that are available currently to clinicians. Here we review the clinical uses of eye tracking, with both an historical and contemporary view. We also consider several new imaging technologies that are becoming available in clinics and include inbuilt eye-tracking capability. These highly sensitive eye trackers should be useful for evaluating a variety of subtle, but important, oculomotor signs and disorders.Vision research 02/2013; 90. DOI:10.1016/j.visres.2013.02.001 · 2.38 Impact Factor
- Journal of Ophthalmology 02/2013; 2013:312974. DOI:10.1155/2013/312974 · 1.94 Impact Factor