Neuroprotective effect of oleuropein following spinal cord injury in rats.

Lorestan University of Medical Sciences, Khorramabad, Iran.
Neurological Research (Impact Factor: 1.45). 01/2012; 34(1):44-51. DOI: 10.1179/1743132811Y.0000000058
Source: PubMed

ABSTRACT Oleuropein (OE) is a well-known antioxidant polyphenol from olive oil. The purpose of this study was to determine the potential neuroprotective effects of oleuropein in an experimental spinal cord injury model.
Rats were randomly divided into four groups of 21 rats each as follows: sham-operated group, trauma group, and OE treatment groups (20 mg/kg, i.p., immediately and 1 hour after spinal cord injury). Spinal cord samples were taken 24 hours after injury and studied for determination of malondialdehyde and glutathione levels, histopathological assessment, immunohistochemistry of Bax and Bcl-2, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling reaction. Behavioral testing was performed weekly up to 6 weeks post-injury.
The results showed that malondialdehyde levels were significantly decreased, and glutathione levels were significantly increased in OE treatment groups. Greater Bcl-2 and attenuated Bax expression could be detected in the OE-treated rats. OE significantly reduced terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive reaction and improved behavioral function than the trauma group.
These findings indicate that OE may be effective in protecting rat spinal cord from secondary injury.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Oleuropein is a natural antioxidant and scavenging free radicals. In the present study, we examined effect of oleuropein on hemoglobin A1C, serum glucose, lipid profile and atherogenic index in alloxan-induced Type 1 diabetic rats. Thirty Sprage-dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with oleuropein by 15 mg/kg i.p daily, respectively .Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, the levels of hemoglobin A1C, fasting blood glucose (FBG), triglyceride (TG), cholesterol (C), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) and atherogenic index of all groups were analyzed. Oleuropein significantly decreased hemoglobin A1C, FBG, TG, C, LDL and VLDL. HDL level was significantly increased when treated with oleuropein. The findings of the present study suggest that oleuropein exert beneficial effects on serum serum glucose, hemoglobin A1C, lipid profile and atherogenic index in alloxan-induced Type 1 diabetic rats.
    Asian Pacific Journal of Tropical Disease. 01/2014; 4.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The use of the products derived from the olive tree on human health dates back centuries. In several civilizations, the olive tree had and still has a very strong cultural and religious symbolism. Notably, the official seal and emblem of the World Health Organization features the rod of Asclepius over a world map surrounded by olive tree branches, chosen as a symbol of peace and health. Recently, accumulating experimental, clinical and epidemiological data have provided support to the traditional beliefs of the beneficial effect provided by olive derivates. In particular, the polyphenols present in olive leaves, olives, virgin (unrefined) olive oil and olive mill waste are potent antioxidant and radical scavengers with anti-tumor and anti-inflammatory properties. Here, we review the positive impact on human health of oleuropein, the most prevalent polyphenol present in olives. In addition, we provide data collected in our laboratory on the role of oleuropein in counteracting lipid accumulation in a mouse model of non-alcoholic fatty liver disease.
    International Journal of Molecular Sciences 10/2014; 15(10):18508-18524. · 2.34 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. Thus, a protective action has been demonstrated in preclinical studies against several diseases, especially cardiovascular and metabolic disorders.The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds.
    Journal of Translational Medicine 08/2014; 12(1):219. · 3.99 Impact Factor


Available from
May 29, 2014