Article

Characterization of Pseudomonas aeruginosa isolates from dogs and cats in Japan: current status of antimicrobial resistance and prevailing resistance mechanisms.

Laboratory of Veterinary Microbiology, Nippon Veterinary and Life Science University 1-7-1, Kyonan-cho, Musashino, Tokyo, 180-8602, Japan.
Microbiology and Immunology (impact factor: 1.3). 12/2011; 56(2):123-7. DOI:10.1111/j.1348-0421.2011.00416.x
Source: PubMed

ABSTRACT Seventy-three Pseudomonas aeruginosa isolates were collected from dogs and cats in Japan to investigate antimicrobial susceptibility and resistance mechanisms to anti-pseudomonal agents. Resistance rates against orbifloxacin, enrofloxacin, ciprofloxacin, cefotaxime, aztreonam and gentamicin were 34.2, 31.5, 20.5, 17.8, 12.3 and 4.1%, respectively. The degree of resistance to cefotaxime, orbifloxacin, and enrofloxacin was greatly affected by efflux pump inhibitors, indicating overexpression of efflux pump contributes to these resistances. Notably, orbifloxacin and enrofloxacin resistance was observed even in isolates without mutations in the target sites. This is the first report on cephalosporin- and fluoroquinolone-resistant isolates of P. aeruginosa from Japanese companion animals.

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Keywords

efflux pump contributes
 
efflux pump inhibitors
 
enrofloxacin resistance
 
first report
 
fluoroquinolone-resistant
 
gentamicin
 
Japan
 
Japanese companion animals
 
mutations
 
orbifloxacin
 
overexpression
 
P. aeruginosa
 
Pseudomonas aeruginosa
 
resistance mechanisms
 
Resistance rates
 
resistances
 
target sites
 

Kazuki Harada