Use and Usefulness of Adrenal Core Biopsies Without FNA or On-site Evaluation of Adequacy A Study of 204 Cases for a 12-Year Period

Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA.
American Journal of Clinical Pathology (Impact Factor: 3.01). 01/2012; 137(1):124-31. DOI: 10.1309/AJCP4JE4FVDJFLIJ
Source: PubMed

ABSTRACT While several studies have assessed the efficacy of adrenal fine-needle aspiration, there are few data regarding adrenal tissue core biopsies. We performed a retrospective study, for a 12-year period, of 204 percutaneous adrenal core biopsy specimens. A core was the only specimen obtained, and on-site evaluation was not used. About half of the cases (104/204) were diagnosed as metastatic carcinoma, with lung as the most common origin (78/204). A specificity and sensitivity of 100% for benign vs malignant was calculated, with a specificity of 88% and sensitivity of 86% for specific diagnoses. Diagnostic and sampling errors were identified. False-negatives were limited to biopsies using 20-gauge needles. Cases with a clinical history provided had specific diagnoses made at a slightly higher frequency compared with cases without an available history. Immunohistochemical workup was performed in more than half of the cases; specific diagnoses were made more frequently than in cases without immunostains.

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