Antimycobacterial activities of 5-alkyl (or halo)-3 '-substituted pyrimidine nucleoside analogs

Department of Laboratory Medicine and Pathology, 1-71 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7.
Bioorganic & medicinal chemistry letters (Impact Factor: 2.42). 12/2011; 22(2):1091-4. DOI: 10.1016/j.bmcl.2011.11.114
Source: PubMed


Several 5-alkyl (or halo)-3'-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3'-azido-5-ethyl-2',3'-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC(50)=1μg/mL), M. tuberculosis (MIC(50)=10μg/mL) and M. avium (MIC(50)=10μg/mL).

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