Article

The dialog between microbiota and the immune system: Shaping the partners through development and evolution

INSERM, U989, Paris, France
Seminars in Immunology (Impact Factor: 6.12). 12/2011; 24(1):1-2. DOI: 10.1016/j.smim.2011.11.007
Source: PubMed
1 Follower
 · 
94 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Recent studies highlight an important role of the aryl hydrocarbon receptor (AhR) at mucosal barriers. Surprisingly, activation of the AhR, required for the maintenance of lymphocytes as well as lymphoid architecture, can be achieved via cues derived from the external environment. This environment contains both beneficial and harmful microorganisms as well as a diverse array of compounds, and the epithelia must offer very sophisticated levels of defence. This is achieved via multifaceted immune recognition diversity and cellular complexity. Mucosal associated tissues, particularly in the gastrointestinal tract, constitute a complex immune organ for local lymphocytes and contain highly organised lymphoid structures. We will discuss the recent observations concerning the AhR in relation to the function and maintenance of innate T cells, with focus on γδ T cells found enriched at epithelial barriers.
    Seminars in Immunopathology 09/2013; 35(6). DOI:10.1007/s00281-013-0389-1 · 6.48 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Immune system is well characterized by immunologists into two major arms called Innate immunity and Adaptive immunity. However, recent advances in the field of immunology has led to the identification of specific immune cells, which lack signature signs of mature lymphocytes (i.e. Antigen receptors), yet produce major cytokines (i.e. IFN-γ, IL-4, IL-5, IL-13, IL-9 etc.) of helper T (Th) cell mediated immune response. Therefore, these cells can be represented as the innate counterpart of helper T cells of adaptive immunity and are known as innate lymphoid cells (ILCs). These ILCs comprise of three different groups having different kinds of cells, i.e. group 1 (NK cells and ILC1 cells), group 2 and group 3 ILCs. However, they are also emerging as novel regulators of both chronic as well as acute inflammation induced by infection or caused by sterile inflammation. Therefore, an attempt has been made to highlight the regulatory role of ILCs during inflammation and modulation of these cells as novel tissue protective mechanism.
    Immunology letters 11/2013; 157(1-2). DOI:10.1016/j.imlet.2013.11.003 · 2.37 Impact Factor
  • Source
    Nephrology Dialysis Transplantation 03/2015; · 3.49 Impact Factor