Synthesis and cytotoxicity of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates.

Key Laboratory of Pesticide and Chemical Biology, Ministry of Education and College of Chemistry, Central China Normal University, Wuhan 430079, PR China.
European Journal of Medicinal Chemistry (Impact Factor: 3.43). 12/2011; 48:379-84. DOI: 10.1016/j.ejmech.2011.12.014
Source: PubMed

ABSTRACT A series of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC(50) 7.1 and 11.4 μM, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that of fluorouracil.

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