Article

Induction of Treg cells in the mouse colonic mucosa: a central mechanism to maintain host-microbiota homeostasis.

Department of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Seminars in Immunology (impact factor: 6.39). 12/2011; 24(1):50-7. DOI:10.1016/j.smim.2011.11.009 pp.50-7
Source: PubMed

ABSTRACT CD4+ regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis.

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Keywords

associate intestinal microbiota
 
CD4+ regulatory T
 
Foxp3
 
immunological homeostasis
 
inflammatory bowel disease
 
intestinal immune homeostasis
 
intestinal microbiota influence
 
mouse intestinal lamina propria
 
Recent studies
 
transcription factor forkhead box P3
 
Treg cells
 

Takeshi Tanoue