Detection of Mobile-Genetic-Element Variation between Colonizing and Infecting Hospital-Associated Methicillin-Resistant Staphylococcus aureus Isolates

Centre for Infection, Division of Clinical Sciences, St George’s University of London, London, United Kingdom.
Journal of clinical microbiology (Impact Factor: 4.23). 12/2011; 50(3):1073-5. DOI: 10.1128/JCM.05938-11
Source: PubMed

ABSTRACT Whole-genome analysis by 62-strain microarray showed variation in resistance and virulence genes on mobile genetic elements (MGEs) between 40 isolates of methicillin-resistant Staphylococcus aureus (MRSA) strain CC22-SCCmecIV but also showed (i) detection of two previously unrecognized MRSA transmission events and (ii) that 7/8 patients were infected with a variant of their own colonizing isolate.

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