Article

Polymorphisms in complement system genes and risk of non-Hodgkin lymphoma.

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892-7240, USA.
Environmental and Molecular Mutagenesis (impact factor: 3.71). 12/2011; 53(2):145-51. DOI:10.1002/em.21675
Source: PubMed

ABSTRACT The complement system plays an important role in inflammatory and immune responses, and recent evidence has suggested that it may also play a role in lymphomagenesis. We evaluated the association between genetic variation in complement system genes and risk of non-Hodgkin lymphoma (NHL) in a population-based case-control study conducted among women in Connecticut. Tag SNPs in 30 complement genes were genotyped in 432 Caucasian incident cases and 494 frequency-matched controls. A gene-based analysis that adjusted for the number of tag SNPs genotyped in each gene showed a significant association with NHL overall (P = 0.04) as well as with diffuse large B-cell lymphoma (DLBCL) (P = 0.01) for the C1RL gene. A SNP-based analysis showed that a C>T base substitution for C1RL rs3813729 (odds ratio (OR)(CT) = 0.60, 95% confidence interval (CI) = 0.42-0.87, P(trend) = 0.0062) was associated with a decreased risk of overall NHL, as well as for DLBCL (OR(CT) = 0.39, 95% CI = 0.20-0.73; P(trend) = 0.0034). Additionally, SNPs (C2 rs497309, A>C and C3 rs344550, G>C) in two complement genes were positively associated with marginal zone lymphoma (MZL) and C1QG was associated with CLL/SLL, but these results were based on a limited number of cases. Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings.

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Keywords

432 Caucasian incident cases
 
494 frequency-matched controls
 
95% confidence interval
 
complement system
 
decreased risk
 
diffuse large B-cell lymphoma
 
gene-based analysis
 
genetic variation
 
immune responses
 
lymphomagenesis
 
marginal zone lymphoma
 
non-Hodgkin lymphoma
 
odds ratio
 
population-based case-control study
 
potential role
 
preliminary findings
 
SNP-based analysis
 
system genes
 
Tag SNPs
 
tag SNPs genotyped