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Verification of the genomic identity of candidate microchimeric cells.

Peter Sedlmayr, Thomas Kroneis

Center for Molecular Medicine; Institute of Cell Biology, Histology and Embryology; Medical University of Graz; Graz, Austria.

Journal Article: Chimerism (Print) 01/2011; 2(3):63-64. DOI: 10.4161/chim.2.3.17741

Abstract

Microchimerism has been studied in the context of a variety of diseases which include autoimmune diseases (such as systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and autoimmune thyroid diseases), cancer (e.g., of the cervix, thyroid gland, lung, breast), tissue repair, transplantation and transfusion. It may become relevant in the context of cell-based non-invasive prenatal diagnosis. But how to safely identify individual microchimeric cells? This is a nontrivial question, for which a solution has recently been suggested.

Source: PubMed

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Keywords

autoimmune thyroid diseases
 
cell-based non-invasive prenatal diagnosis
 
cervix
 
diseases
 
include autoimmune diseases
 
individual microchimeric cells
 
relevant
 
rheumatoid arthritis
 
transfusion