Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients

Virology Department, Amiens University Hospital, South Hospital, Amiens, France.
Journal of clinical microbiology (Impact Factor: 4.23). 12/2011; 50(2):465-8. DOI: 10.1128/JCM.06503-11
Source: PubMed

ABSTRACT HCV core antigen (Ag) and HCV RNA levels were evaluated in matched liver biopsy samples and sera from 22 patients with hepatitis C infection by using the quantitative Architect HCV Ag immunoassay and a real-time RT-qPCR assay, respectively. The data showed a strong correlation between liver and serum compartments of HCV Ag levels (r = 0.80) and HCV RNA levels (r = 0.87). In summary, the serum HCV Ag and RNA levels reflect the intrahepatic values.


Available from: Veronique Descamps, May 30, 2015
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