Copper-free click--a promising tool for pre-targeted PET imaging.

Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, United Kingdom.
Chemical Communications (Impact Factor: 6.38). 12/2011; 48(7):991-3. DOI: 10.1039/c1cc16220a
Source: PubMed

ABSTRACT The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [(18)F]2-fluoroethylazide ([(18)F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

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