Article

The role of ubiquitylation in immune defence and pathogen evasion.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA.
Nature Reviews Immunology (impact factor: 32.25). 12/2011; 12(1):35-48. DOI:10.1038/nri3111 pp.35-48
Source: PubMed

ABSTRACT Ubiquitylation is a widely used post-translational protein modification that regulates many biological processes, including immune responses. The role of ubiquitin in immune regulation was originally uncovered through studies of antigen presentation and the nuclear factor-κB family of transcription factors, which orchestrate host defence against microorganisms. Recent studies have revealed crucial roles of ubiquitylation in many aspects of the immune system, including innate and adaptive immunity and antimicrobial autophagy. In addition, mounting evidence indicates that microbial pathogens exploit the ubiquitin pathway to evade the host immune system. Here, we review recent advances on the role of ubiquitylation in host defence and pathogen evasion.

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Keywords

adaptive immunity
 
antigen presentation
 
aspects
 
crucial roles
 
host defence
 
host immune system
 
immune responses
 
immune system
 
microorganisms
 
nuclear factor-κB family
 
orchestrate host defence
 
Recent studies
 
regulates
 
ubiquitin
 
ubiquitin pathway
 
Ubiquitylation
 
used post-translational protein modification
 

Xiaomo Jiang