Article

SnapShot: Retinoic Acid Signaling

Sanford-Burnham Medical Research Institute, Development and Aging Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell (Impact Factor: 33.12). 12/2011; 147(6):1422-1422.e1. DOI: 10.1016/j.cell.2011.11.034
Source: PubMed
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Available from: Sandeep Kumar, Aug 28, 2015
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    • "During embryonic development, retinoic acid (RA) acts as a morphogen, providing signals that instruct commitment of unspecified precursors toward separate cell fates, thereby helping to mediate tissue patterning and organogenesis (Duester, 2008; Kumar and Duester, 2011; Ross et al., 2000). As such, RA is also a potent teratogen capable of disturbing developmental processes, causing severe malformations of the fetus. "
    Dataset: 2015-Ronn
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    • "Retinoic acid (RA) is a lipid-soluble signaling molecule derived from vitamin A (retinol) that regulates a diverse array of biological processes, including cellular proliferation, differentiation, and apoptosis throughout embryonic development (Kumar and Duester, 2011). "
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    • "Retinoic acid, a metabolite of retinoin, promotes lung maturation and inhibits androgen receptor levels and function in several organs [24-27]. Further, testosterone has been shown to modulate retinoic acid activity in the lacrimal gland [28]. "
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    ABSTRACT: Background MicroRNAs play important roles in regulating biological processes, including organ morphogenesis and maturation. However, little is known about specific pathways regulated by miRNA during lung development. Between the canalicular and saccular stages of the developing lung several important cellular events occur, including the onset of surfactant synthesis, microvascular remodeling and structural preparation for subsequent alveolarization. The miRNAs that are actively regulated, and the identity of their targets during this important developmental interval in the lung remain elusive. Results Using TLDA low density real-time PCR arrays, the expression of 376 miRNAs in male and female fetal mouse lungs of gestational days E15 – E18 were profiled. Statistical analyses identified 25 and 37 miRNAs that changed significantly between sexes and with gestation, respectively. In silico analysis using Ingenuity Pathway Analysis (IPA) identified specific pathways and networks known to be targets of these miRNAs which are important to lung development. Pathways that are targeted by sex regulated miRNAs include retinoin, IGFR1, Tp53 and Akt. Pathways targeted by gestation-regulated miRNAs include VEGFA and mediators of glucose metabolism. Conclusion MiRNAs are differentially regulated across time and between sexes during the canalicular and saccular stages of lung development. Sex-associated differential miRNA expression may regulate the differences in structural and functional male and female lung development, as shown by networks generated using in silico analysis. These data provide a valuable resource to further enhance the understanding of miRNA control of lung development and maturation.
    BMC Developmental Biology 04/2013; 13(1):13. DOI:10.1186/1471-213X-13-13 · 2.75 Impact Factor
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