Dengue: a newly emerging viral infection in Andaman and Nicobar Islands, India
ABSTRACT Prior to 2009 dengue fever had not been reported in the Andaman and Nicobar archipelago. In 2009, a few patients with dengue fever-like illness were reported, some of whom tested positive for dengue antibodies. In 2010, 516 suspected cases were reported, including some with dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS); 80 (15·5%) were positive for dengue antibodies. DENV RNA was detected in five patients and PCR-based typing showed that three of these belonged to serotype 1 and two to serotype 2. This was confirmed by sequence typing. Two clones of dengue virus, one belonging to serotype 1 and the other to serotype 2 appeared to be circulating in Andaman. Emergence of severe diseases such as DHF and DSS might be due to recent introduction of a more virulent strain or because of the enhancing effect of sub-neutralizing levels of antibodies developed due to prior infections. There is a need to revise the vector-borne disease surveillance system in the islands.
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ABSTRACT: Objective To identify the possible association of killer cell immunoglobulin like receptors (KIRs) gene polymorphisms in patients with dengue virus infection. Methods Seventeen known KIRs were determined in 30 dengue patients and 40 healthy individuals by the sequence specific primer polymerase chain reaction method. Associations with specific KIR genes were tested using the Chi-squared test and Fisher test using EpiInfo 7 software. Results All frame work genes and pseudo genes were detected among 97% and 98% of all dengue cases and healthy individuals respectively. The total carriage frequency of KIR3DL1 and KIR2DL2 were decrease in dengue patients compared with healthy individuals (P=0.000 0 and P=0.000 5 respectively) from A haplotype and inhibitory receptors. Conclusions The KIR polymorphisms may be associated with susceptibility to dengue virus infection. It could be suggested that KIR3DL1 and KIR2DL2 were susceptibility genes for dengue virus. However, these findings provide certain support for hypothesis, that KIR genes influence susceptibility and may play a role in the clearance of dengue virus infection.01/2015; 5(1):47–50. DOI:10.1016/S2222-1808(14)60625-3
Journal of Asia-Pacific Entomology 12/2014; 17(4):761–766. DOI:10.1016/j.aspen.2014.07.007 · 0.88 Impact Factor