The Netherlands study of depression in older persons (NESDO); a prospective cohort study.

Department Psychiatry/EMGO Institute for Health and Care Research, VU University Medical Center/GGZinGeest, Amsterdam, The Netherlands. .
BMC Research Notes 12/2011; 4:524. DOI: 10.1186/1756-0500-4-524
Source: PubMed

ABSTRACT To study late-life depression and its unfavourable course and co morbidities in The Netherlands.
We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood.
From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons (≥ 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years.
The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons.

1 Bookmark
  • [Show abstract] [Hide abstract]
    ABSTRACT: Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain characteristics of depressed older adults and a non-depressed comparison group and 2) to explore physical, lifestyle, psychological and social determinants of acute and chronic pain intensity, disability and multisite pain in depressed older adults. Data of the NESDO cohort, consisting of 378 depressed persons, diagnosed according to DSM-IV criteria, and 132 non-depressed persons of 60 years and older, were used in a cross-sectional design. Pain characteristics were measured by the Chronic Graded Pain Scale. Multiple linear regression analyses were performed to explore the contribution of physical, lifestyle, psychological and social determinants to outcomes pain intensity, disability and the number of painlocations. Depressed older adults more often reported chronic pain and experienced their pain as more intense and disabling compared to non-depressed older adults. Adjusted for demographic, physical and lifestyle characteristics, multinominal logistic regression analyses showed increased odds ratios for depression in acute pain ([OR] = 3.010; p = .005) and chronic pain ([OR] = 4.544, p < .001). In addition, linear regression analyses showed acute and chronic pain intensity, disability and multisite pain were associated with several biopsychosocial determinants of which anxiety was most pronounced. Further research could focus on the temporal relationship between anxiety, late-life depression and pain.
    Pain 07/2014; · 5.64 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Although it is well established that late-life depression is associated with both systemic low-graded inflammation and cognitive impairment, the relation between inflammation and cognition in depressed older persons is still equivocal. The objective of this study is to examine the association between plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) concentrations and cognitive functioning in late-life depression, including the potentially moderating role of sex.
    Psychoneuroendocrinology 06/2014; 48C:169-177. · 5.59 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objectives To evaluate the relation of vascular risk factors, subclinical and manifest vascular disease with four domains of cognitive functioning in a large sample of clinically depressed older persons. Design Cross-sectional analysis Setting and Participants: Depressed patients were recruited from general practices and mental health care institutes. Presence of a DSM-IV depressive episode was established with the Composite International Diagnostic Interview. Measure ments: Framingham Risk Score (FRS) was used as a measure for vascular risk profile, ankle-brachial index for subclinical vascular disease and history of a cardiovascular event as a measure for manifest vascular disease. Three neurocognitive tasks evaluated processing speed, working memory, verbal memory and interference control. Results In 378 participants, linear regression analysis showed that FRS was related to poorer interference control (t=-2.353; df=377; p<0.05), but to no other cognitive domain after adjustment for age, sex, education level and depressive symptom severity. Lower ankle brachial index and history of cardiovascular event were related to slower processing speed (t=2.659; df=377; p<0.05 and t=-3.328; df=377; p<0.01 respectively), but to no other cognitive domain. In 267 participants without manifest vascular disease, higher FRS was related to slower processing speed (t=-2.425; df=266; p<0.05) and poorer interference control (t=-2.423; df=266; p<0.05), and lower ankle brachial index was related to slower processing speed (t=2.171; df=266; p<0.05). Conclusions In depressed older persons, vascular burden is related to slower processing speed, also in the absence of manifest vascular disease. Poorer interference control was only related to vascular risk factors, but not to subclinical or manifest vascular disease.
    American Journal of Geriatric Psychiatry 07/2014; · 4.13 Impact Factor

Full-text (2 Sources)

Available from
May 16, 2014