The Netherlands study of depression in older persons (NESDO); a prospective cohort study.

Department Psychiatry/EMGO Institute for Health and Care Research, VU University Medical Center/GGZinGeest, Amsterdam, The Netherlands. .
BMC Research Notes 12/2011; 4:524. DOI: 10.1186/1756-0500-4-524
Source: PubMed

ABSTRACT To study late-life depression and its unfavourable course and co morbidities in The Netherlands.
We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood.
From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons (≥ 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years.
The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons.

1 Bookmark
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Depression among older adults is associated with both disability and somatic disease. We aimed to further understand this complicated relationship and to study the possible modifying effect of increasing age.
    Journal of affective disorders. 06/2014; 167C:187-191.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To compare alcohol use between depressed and nondepressed older adults, and to investigate correlates of alcohol abstinence and at-risk alcohol consumption in depressed older adults. Cross-sectional study. Netherlands Study of Depression in Older Persons (NESDO). A total of 373 participants (mean [standard deviation] age: 70.6 [7.3] years; 66% women) diagnosed with a depressive disorder, and 128 nondepressed participants. Alcohol use was assessed with the Alcohol Use Disorders Identification Test (AUDIT). Participants were categorized into abstainers (AUDIT score: 0), moderate drinkers (AUDIT score: 1-4), and at-risk drinkers (AUDIT score: ≥5). Multinomial logistic regression analysis was performed with AUDIT categories as outcome, and demographic, social, somatic, and psychological variables as determinants. The depressed group consisted of 40.2% abstainers, 40.8% moderate drinkers, and 19.0% at-risk drinkers. The depressed participants were more often abstinent and less often moderate drinkers than the nondepressed participants; they did not differ in at-risk drinking. Depressed abstainers more often used benzodiazepines but less often used antidepressants, and they had a poorer cognitive function than depressed moderate drinkers. Depressed at-risk drinkers were more often smokers and had fewer functional limitations but more severe depressive symptoms than depressed moderate drinkers. Although alcohol abstinence was more common in depressed than in nondepressed older adults, 19% of depressed persons were at-risk drinkers. Because at-risk drinking is associated with more severe depression and may have a negative impact on health and treatment outcome, it is important that physicians consider alcohol use in depressed older adults.
    The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry 07/2013; · 3.35 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain characteristics of depressed older adults and a non-depressed comparison group and 2) to explore physical, lifestyle, psychological and social determinants of acute and chronic pain intensity, disability and multisite pain in depressed older adults. Data of the NESDO cohort, consisting of 378 depressed persons, diagnosed according to DSM-IV criteria, and 132 non-depressed persons of 60 years and older, were used in a cross-sectional design. Pain characteristics were measured by the Chronic Graded Pain Scale. Multiple linear regression analyses were performed to explore the contribution of physical, lifestyle, psychological and social determinants to outcomes pain intensity, disability and the number of painlocations. Depressed older adults more often reported chronic pain and experienced their pain as more intense and disabling compared to non-depressed older adults. Adjusted for demographic, physical and lifestyle characteristics, multinominal logistic regression analyses showed increased odds ratios for depression in acute pain ([OR] = 3.010; p = .005) and chronic pain ([OR] = 4.544, p < .001). In addition, linear regression analyses showed acute and chronic pain intensity, disability and multisite pain were associated with several biopsychosocial determinants of which anxiety was most pronounced. Further research could focus on the temporal relationship between anxiety, late-life depression and pain.
    Pain 07/2014; · 5.64 Impact Factor

Full-text (2 Sources)

Available from
May 16, 2014