The Netherlands study of depression in older persons (NESDO); A prospective cohort study

Department Psychiatry/EMGO Institute for Health and Care Research, VU University Medical Center/GGZinGeest, Amsterdam, The Netherlands. .
BMC Research Notes 12/2011; 4(1):524. DOI: 10.1186/1756-0500-4-524
Source: PubMed


To study late-life depression and its unfavourable course and co morbidities in The Netherlands.
We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood.
From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons (≥ 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years.
The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons.

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    • "The current study used data from the Netherlands Study of Depression in Older Persons (NESDO; age Z60 years), a multi-site prospective cohort study designed to examine the course and consequences of late-life depression (Comijs et al., 2011). Recruitment took place in five regions in the Netherlands from mental health care institutes, ambulatory and clinical mental health care, and general practices. "
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    ABSTRACT: Although depression and loneliness are common among older adults, the role of loneliness on the prognosis of late-life depression has not yet been determined. Therefore, we examined the association between loneliness and the course of depression. We conducted a 2-year follow-up study of a cohort from the Netherlands Study of Depression in Older Persons (NESDO). This included Dutch adults aged 60-90 years with a diagnosis of major depression, dysthymia, or minor depression according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. We performed regression analyses to determine associations between loneliness at baseline and both severity and remission of depression at follow-up. We controlled for potential confounders and performed multiple imputations to account for missing data. Of the 285 respondents, 48% were still depressed after 2 years. Loneliness was independently associated with more severe depressive symptoms at follow-up (beta 0.61; 95% CI 0.12-1.11). Very severe loneliness was negatively associated with remission after 2 years compared with no loneliness (OR 0.25; 95% CI 0.08-0.80). Despite using multiple imputation, the large proportion of missing values probably reduces the study's precision. Generalizability to the general population may be limited by the overrepresentation of ambulatory patients with possibly more persistent forms of depression. In this cohort, the prognosis of late-life depression was adversely affected by loneliness. Health care providers should seek to evaluate the degree of loneliness to obtain a more reliable assessment of the prognosis of late-life depression. Copyright © 2015 Elsevier B.V. All rights reserved.
    Journal of Affective Disorders 06/2015; 185:1-7. DOI:10.1016/j.jad.2015.06.036 · 3.38 Impact Factor
    • "Also, local feasibility certificates were provided by each participating institution. For more details on recruitment and research procedures of the NESDO study, see [11] "
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    ABSTRACT: Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain characteristics of depressed older adults and a non-depressed comparison group and 2) to explore physical, lifestyle, psychological and social determinants of acute and chronic pain intensity, disability and multisite pain in depressed older adults. Data of the NESDO cohort, consisting of 378 depressed persons, diagnosed according to DSM-IV criteria, and 132 non-depressed persons of 60 years and older, were used in a cross-sectional design. Pain characteristics were measured by the Chronic Graded Pain Scale. Multiple linear regression analyses were performed to explore the contribution of physical, lifestyle, psychological and social determinants to outcomes pain intensity, disability and the number of painlocations. Depressed older adults more often reported chronic pain and experienced their pain as more intense and disabling compared to non-depressed older adults. Adjusted for demographic, physical and lifestyle characteristics, multinominal logistic regression analyses showed increased odds ratios for depression in acute pain ([OR] = 3.010; p = .005) and chronic pain ([OR] = 4.544, p < .001). In addition, linear regression analyses showed acute and chronic pain intensity, disability and multisite pain were associated with several biopsychosocial determinants of which anxiety was most pronounced. Further research could focus on the temporal relationship between anxiety, late-life depression and pain.
    Pain 07/2014; 155(10). DOI:10.1016/j.pain.2014.07.019 · 5.21 Impact Factor
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    • "The CIDI is a structured clinical interview that is designed for use in research settings and has high validity for depressive and anxiety disorders (Kessler et al., 2010;Wittchen et al., 1991). Questions were added to determine the research DSM-IV diagnosis of current minor depression (Comijs et al., 2011). "
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    ABSTRACT: BACKGROUND: Little is known about the role of childhood abuse in late-life depression. The aim of the study is therefore to study whether childhood abuse is associated with late-life depression according to its onset, and which clinical characteristics play a role in this association. METHODS: Data were used from 378 depressed and 132 non-depressed persons, aged 60-93 years, from the Netherlands Study of Depression in Older persons (NESDO). Childhood abuse included psychological, physical and sexual abuse and emotional neglect. RESULTS: 53% of the depressed older adults reported childhood abuse, compared to 16% of the non-depressed older adults (p<0.001). Using logistic regression analyses adjusted for age, sex and level of education, depression was strongest associated with physical abuse (Odds Ratio ((OR) 13.71; 95% Confidence Interval (CI) 3.25-57.91) and least with sexual abuse (OR 5.35; 95% CI 2.36-12.14). Childhood abuse was associated with early-onset (OR 13.73, 95% CI 7.31-25.80), middle age-onset (OR 5.36, 95% CI 2.90-9.90) and late-onset depression (OR 4.74, 95% CI 2.51-8.95). In the late-onset group childhood abuse was associated with an increased number of chronic diseases. LIMITATIONS: Age of depression onset and childhood abuse were asked retrospectively, which may have biased the results. CONCLUSIONS: Childhood abuse is strongly related to late-life depression and its comorbidities, even in the case of late-onset depression. This might suggest that psychological wellbeing can be maintained throughout middle age, but may be disturbed in later life.
    Journal of Affective Disorders 11/2012; 147(1-3). DOI:10.1016/j.jad.2012.11.010 · 3.38 Impact Factor
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