Inhibitory Activity of alpha-Amylase and alpha-Glucosidase by Plant Extracts from the Brazilian Cerrado

Department of Pharmaceutical Sciences, School of Health Sciences, Campus Darcy Ribeiro, University of Brasília, Brasília, Brazil.
Planta Medica (Impact Factor: 2.15). 12/2011; 78(4):393-9. DOI: 10.1055/s-0031-1280404
Source: PubMed


Diabetes mellitus is the most common disease in the world. One therapeutic approach for treating diabetes is inhibition of α-amylase and α-glucosidase activities to reduce postprandial blood glucose levels. In vitro tests showed that several plant extracts from Brazilian cerrado species can inhibit the activity of α-amylase and α-glucosidase. The extracts of Eugenia dysenterica, Stryphnodendron adstringens, Pouteria caimito, Pouteria ramiflora, and Pouteria torta showed strong α-amylase and α-glucosidase inhibitory activity. Eugenia dysenterica, P. caimito, P. ramiflora, and P. torta aqueous extracts exerted the highest activity against α-amylase (IC₅₀) values of 14.93, 13.6, 7.08, and 5.67 µg/mL, respectively) and α-glucosidase (IC₅₀ values of 0.46, 2.58, 0.35, and 0.22 µg/mL, respectively). Stryphnodendron adstringens ethanol extract also exhibited inhibitory activity against both enzymes (IC₅₀) 1.86 µg/mL against α-amylase and 0.61 µg/mL against α-glucosidase). The results suggest that the activity of these cerrado plants on α-amylase and α-glucosidase represents a potential tool for development of new strategies for treatment of diabetes.

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    • "In this context, optimization statistical tools such as Response Surface Methodology (RSM) has being successfully applied in understanding the relationship between spray drying parameters and powder properties (Vasconcelos et al., 2005; Marquele et al., 2006; Souza et al., 2007; Jangam & Thorat, 2010; Toneli et al., 2010; Oliveira et al., 2011; Couto et al., 2011; Couto et al., 2012). Eugenia dysenterica DC., Myrtaceae, commonly known as cagaita, was chosen for this research due to its importance in Brazilian folk medicine, as well as its valuable therapeutic potential described in the literature (Costa et al., 2000; Couto et al, 2009; Lima et al., 2010; De Souza et al., 2011; Lima et al., 2011; Vieira et al., 2012). Despite E. dysenterica's medicinal importance, there is a lack of information documenting its behavior during standardization and processing. "
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