Theranostic nanoplatforms for simultaneous cancer imaging and therapy: Current approaches and future perspectives

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
Nanoscale (Impact Factor: 7.39). 12/2011; 4(2):330-42. DOI: 10.1039/c1nr11277e
Source: PubMed


Theranostics is a concept which refers to the integration of imaging and therapy. As an evolving new field, it is related to but different from traditional imaging and therapeutics. It embraces multiple techniques to arrive at a comprehensive diagnostic, in vivo molecular images and an individualized treatment regimen. More recently, there is a trend of tangling these efforts with emerging materials and nanotechnologies, in an attempt to develop novel platforms and methodologies to tackle practical issues in clinics. In this article, topics of rationally designed nanoparticles for the simultaneous imaging and therapy of cancer will be discussed. Several exemplary nanoparticle platforms such as polymeric nanoparticles, gold nanomaterials, carbon nanotubes, magnetic nanoparticles and silica nanoparticles will be elaborated on and future challenges of nanoparticle-based systems will be discussed.

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Available from: Ki Young Choi, Oct 05, 2015
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    • "To significantly improve cancer treatment, more effective diagnostic and therapeutic methods with minimal side effects are needed. For this purpose, polymeric theranostic nanoparticles (PTNPs) that can simultaneously deliver imaging and therapeutic modalities have been investigated extensively for cancer diagnosis and treatment [2]. "
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    • "The development of functionalized iron oxide NPs is of great interest due their wide range of applications in the biomedical field. The composition, size, and morphology of the NP inorganic core are now modulated to combine properties in therapy (magnetic hyperthermia) and diag­ nosis (MRI) and to develop theranostic agents [1] [2] [3] [4] [5] [6] [7] [8]. However, regarding biomedical applications, these NPs should always be functionalized with organic molecules to ensure at first their biocompatibility and biodistribu­ tion. "
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    • "Many anticancer drugs, such as doxorubicin (DOX) and camptothecin, cannot elicit therapeutic action unless they enter into nuclei. The slow release of the drug inside cells would retard the influx of the drug into cellular nuclei, which is mainly governed by the concentration gradient between the cytoplasm and the nucleus [12] [13]. In addition, a long residence inside lysosomes increases the risk of drug deactivation. "
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