Animal Models of Dyssynchrony

Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Journal of Cardiovascular Translational Research (Impact Factor: 3.02). 12/2011; 5(2):135-45. DOI: 10.1007/s12265-011-9336-5
Source: PubMed

ABSTRACT Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the underlying conduction disease and resynchronization. In this review, we discuss to what extent established and novel animal models can help to better understand the pathophysiology of dyssynchrony and the benefits of CRT.

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The online version of this article (doi:10.1007/s12265-011-9336-5) contains supplementary material, which is available to authorized users.

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