Article

Analysis of skeletal muscle hypertrophy in models of increased loading.

Department of Neurobiology, University of California, Davis, CA, USA.
Methods in molecular biology (Clifton, N.J.) 01/2012; 798:213-29. DOI:10.1007/978-1-61779-343-1_12 pp.213-29
Source: PubMed

ABSTRACT Skeletal muscle is a highly adaptive tissue that modifies its size in response to a variety of external stimuli. In adult mammals, skeletal muscle hypertrophy occurs primarily as a response to increases in external loading. Here, we describe the methods that should be used for a comprehensive assessment of muscle hypertrophy in animal models. The methods include the measurement of muscle mass, fiber cross-sectional area, contractile function, and protein concentration.

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Keywords

adaptive tissue
 
adult mammals
 
contractile function
 
external loading
 
external stimuli
 
modifies
 
muscle hypertrophy
 
muscle mass
 
Skeletal muscle
 
skeletal muscle hypertrophy