Probiotic yogurt improves antioxidant status in type 2 diabetic patients

Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition (Impact Factor: 2.93). 11/2011; 28(5):539-43. DOI: 10.1016/j.nut.2011.08.013
Source: PubMed


Oxidative stress plays a major role in the pathogenesis and progression of diabetes. Among various functional foods with an antioxidant effect, probiotic foods have been reported to repress oxidative stress. The objective of this clinical trial was to assess the effects of probiotic and conventional yogurt on blood glucose and antioxidant status in type 2 diabetic patients.
Sixty-four patients with type 2 diabetes mellitus, 30 to 60 y old, were assigned to two groups in this randomized, double-blind, controlled clinical trial. The patients in the intervention group consumed 300 g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group consumed 300 g/d of conventional yogurt for 6 wk. Fasting blood samples, 24-h dietary recalls, and anthropometric measurements were collected at the baseline and at the end of the trial.
Probiotic yogurt significantly decreased fasting blood glucose (P < 0.01) and hemoglobin A1c (P < 0.05) and increased erythrocyte superoxide dismutase and glutathione peroxidase activities and total antioxidant status (P < 0.05) compared with the control group. In addition, the serum malondialdehyde concentration significantly decreased compared with the baseline value in both groups (P < 0.05). No significant changes from baseline were shown in insulin concentration and erythrocyte catalase activity within either group (P > 0.05).
The consumption of probiotic yogurt improved fasting blood glucose and antioxidant status in type 2 diabetic patients. These results suggest that probiotic yogurt is a promising agent for diabetes management.

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Available from: Aziz Homayouni, Aug 23, 2014
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    • "There are reports of the demonstrated antimicrobial activity of organic acids (Ström et al., 2002; De Muynck et al., 2004), probiotic culture supernatants and their ethyl acetate extracts (Lavermicocca et al., 2000). Besides antimicrobial activity, probiotics are also reported to have antioxidant and anti-ageing activities (Ejtahed et al., 2012; Li et al., 2012). The presence of excessive reactive oxygen species (ROS) such as hydroxyl radicals (OH), superoxide anions ( . "

    09/2015; 4(5). DOI:10.5539/jfr.v4n5p122
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    • "Several studies have also shown that probiotic products could regulate the blood glucose level in diabetic human89. Moreover, L. casei Shirota has been reported to reduce blood glucose level through reducing lipopolysaccharide-binding protein10. "
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    • "Molecular mechanisms involving the anti-diabetic effects of probiotics are not fully elucidated, but may be related to reduction of oxidative stress, immunomodulation, attenuation of inflammation and modification of the intestinal microbiota (Figure 1) [9]. Furthermore, probiotics have been shown to improve the absorption of antioxidants and reduce post-prandial lipid concentrations, actions directly related to oxidative stress [121]. "
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