Nutrigenomics and personalized diets: What will they mean for food?
ABSTRACT The modern food system feeds six billion people with remarkable diversity, safety, and nutrition. Yet, the current rise in diet-related diseases is compromising health and devaluing many aspects of modern agriculture. Steps to increase the nutritional quality of individual foods will assist in personalizing health and in guiding individuals to achieve superior health. Nutrigenomics is the scientific field of the genetic basis for varying susceptibilities to disease and the diverse responses to foods. Although some of these genetic determinants will be simple and amenable to personal genotyping as the means to predict health, in practice most will not. As a result, genotyping will not be the secret to personalizing diet and health. Human assessment technologies from imaging to proteomics and metabolomics are providing tools to both understand and accurately assess the nutritional phenotype of individuals. The business models are also emerging to bring these assessment capabilities to industrial practice, in which consumers will know more about their personal health and seek personal solutions.
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ABSTRACT: Model organisms are an important tool for the development and validation of analytical approaches for proteomics and for the study of basic mechanisms of biological processes. The Initiative on Model Organism Proteomics (iMOP) organized a session during the 11th HUPO world congress in Boston in 2012, highlighting the potential of proteomics studies in model organism for the elucidation of important mechanisms regulating the interaction of humans with its environment. Major subjects were the use of model organisms for the study of molecular events triggering the interaction of host organisms with the surrounding microbiota and the elucidation of the complex influence of nutrition on the health of human beings.Proteomics 09/2013; 13(17):2537-41. DOI:10.1002/pmic.201370144 · 3.97 Impact Factor
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ABSTRACT: In the past 20 years, the scientific community has faced a great development in different fields due to the development of high-throughput, omics technologies. Starting from the four major types of omics measurements (genomics, transcriptomics, proteomics, and metabolomics), a variety of omics subdisciplines (epigenomics, lipidomics, interactomics, metallomics, diseasomics, etc.) has emerged. Thanks to the omics approach, researchers are now facing the possibility of connecting food components, foods, the diet, the individual, the health, and the diseases, but this broad vision needs not only the application of advanced technologies, but mainly the ability of looking at the problem with a different approach, a "foodomics approach". Foodomics is the comprehensive, high-throughput approach for the exploitation of food science in the light of an improvement of human nutrition. Foodomics is a new approach to food and nutrition that studies the food domain as a whole with the nutrition domain to reach the main objective, the optimization of human health and well-being.Genes & Nutrition 08/2012; 8(1). DOI:10.1007/s12263-012-0310-x · 3.42 Impact Factor
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ABSTRACT: Aim: Nutrigenomics reflects gene–diet interactions. In recent years, the science of nutrigenomics has become more sophisticated. We seek to answer the question as to what this might mean for the dietetics profession. Methods: We have critically reviewed recent developments in the area, and considered the importance of new business opportunities being opened up, which exploit the full potential of nutrigenomics for dietitians. Results: Whereas early business models sold genetic test results through direct-to-consumer testing, new business initiatives move dietitians to a central role. This now provides a robust framework that can inform dietitians in their practice. Conclusion: This field represents an important advance for dietitians.Nutrition & Dietetics 09/2012; 69(3-69):198-202. DOI:10.1111/j.1747-0080.2012.01623.x · 0.66 Impact Factor