The cost-effectiveness of varicella and combined varicella and herpes zoster vaccination programmes in the United Kingdom

Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, LondonNW9 5EQ, UK.
Vaccine (Impact Factor: 3.62). 11/2011; 30(6):1225-34. DOI: 10.1016/j.vaccine.2011.11.026
Source: PubMed


Despite the existence of varicella vaccine, many developed countries have not introduced it into their national schedules, partly because of concerns about whether herpes zoster (HZ, shingles) will increase due to a lack of exogenous boosting. The magnitude of any increase in zoster that might occur is dependent on rates at which adults and children mix - something that has only recently been quantified - and could be reduced by simultaneously vaccinating older individuals against shingles. This study is the first to assess the cost-effectiveness of combined varicella and zoster vaccination options and compare this to alternative programmes.

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    • "• Varicella vaccination protects current children from varicella, and years later, protects them from zoster, a more severe disease caused by reactivation of varicella in people who have recovered . In current adults though, vaccination could actually result in higher zoster incidence [31]. Hence, there are important intercohort effects, with benefits to cohorts receiving the vaccine but detriments to older cohorts. "
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