Article

[Effects of the induction of anesthesia with propofol on hemodynamics in patients with Parkinson's disease].

Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, Tokyo 173-8610.
Masui. The Japanese journal of anesthesiology 10/2011; 60(10):1135-43. pp.1135-43
Source: PubMed

ABSTRACT Patients with Parkinson's disease frequently suffer from impaired autonomic nervous function. To elucidate the effects of the induction of anesthesia with propofol on cardiovascular hemodynamics has become important, since the number of patients with Parkinson's disease undergoing deep brain stimulation under general anesthesia has increased recently.
Effects of induction with propofol in patients with Parkinson's disease on cardiovascular hemodynamics and autonomic nervous activity were compared with those of the control patients. Moreover, possible different effect on hemodynamics between the propofol alone and the combination of propofol and fentanyl for the induction were examined in patients with Parkinson's disease.
Although heart rate or blood pressure was not different between patients with Parkinson's disease and the control patients before the induction, sympathetic vasomotor activity was lower in patients with Parkinson's disease than the control patients. The induction of anesthesia significantly decreased blood pressure in patients with Parkinson's disease. However the decreasing systolic blood pressure after the induction of anesthesia was more marked in patients with Parkinson's disease than the control patients. We did not find differences in the changes of blood pressure between the propofol alone and the combination of propofol and fentanyl in patients with Parkinson's disease.
No abnormal responses to the induction of anesthesia with propofol were found in the patients with Parkinson's disease.

0 0
 · 
0 Bookmarks
 · 
59 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

abnormal responses
 
anesthesia
 
autonomic nervous activity
 
autonomic nervous function
 
blood pressure
 
cardiovascular hemodynamics
 
control patients
 
decreasing systolic blood pressure
 
differences
 
elucidate
 
fentanyl
 
general anesthesia
 
heart rate
 
induction
 
Parkinson's disease
 
Parkinson's disease undergoing
 
Patients
 
possible different effect
 
propofol
 
sympathetic vasomotor activity