Occidiofungin's Chemical Stability and In Vitro Potency against Candida Species

Department of Biological Sciences, Mississippi State University, Mississippi State, Mississippi, USA.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.45). 11/2011; 56(2):765-9. DOI: 10.1128/AAC.05231-11
Source: PubMed

ABSTRACT Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.0 μg/ml. Occidiofungin retains its in vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 μg/ml, respectively. Time-kill and postantifungal effect (PAFE) experiments of occidiofungin against Candida albicans were performed. The results demonstrate that occidiofungin is fungicidal. Occidiofungin was also found to be a very stable molecule. It is resistant to extreme temperatures and pH and maintains its activity following exposure to gastric proteases.

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