Article

Packaging of Fat: An Evolving Model of Lipid Droplet Assembly and Expansion

Rutgers Center for Lipid Research and Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA.
Journal of Biological Chemistry (Impact Factor: 4.57). 11/2011; 287(4):2273-9. DOI: 10.1074/jbc.R111.309088
Source: PubMed

ABSTRACT Lipid droplets (LDs) are organelles found in most types of cells in the tissues of vertebrates, invertebrates, and plants, as well as in bacteria and yeast. They differ from other organelles in binding a unique complement of proteins and lacking an aqueous core but share aspects of protein trafficking with secretory membrane compartments. In this minireview, we focus on recent evidence supporting an endoplasmic reticulum origin for LD formation and discuss recent findings regarding LD maturation and fusion.

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    • "In the past decade, LDs have emerged as heterogeneous organelles with great dynamics in size, abundance, and composition in regard to both proteins and lipids.60 Recent studies have provided more details on LD structure, biogenesis, function, and molecular regulation.3,13,15,61,62 Given the conservation among the basic mechanisms of control of lipid metabolism,63 studies in insects41 and other systems have been instrumental to the advancement of this field. "
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