Article

[Correlation studies between urinary retinol binding protein and renal tubular damage].

Huazhong University of Science and Technology,Wuhan, China.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 10/2011; 36(10):1008-11. DOI:10.3969/j.issn.1672-7347.2011.10.013 pp.1008-11
Source: PubMed

ABSTRACT To study correlation between urinary retinol binding protein (RBP) content and renal tubular damage.
A total of 1 353 healthy people and 186 patients with renal tubular damage diagnosed by renal biopsy were enrolled. The indicators such as endogenous creatinine clearance rate (Ccr),creatinine(Cr),urinary retinol binding protein(RBP),urinary β(2)-microglobulin(β(2)-MG),urinary N-acety1-beta-D-glucosaminidase (NAG),urine specific gravity(SG),urine osmolality of the 2 groups were examined and compared. Score of tubulointerstitial impairing and all indicators were analyzed by Spearman rank correlation analysis,and the sensitivity and specificity of indicators were calculated.
Renal tubular damage was positively correlated with urinary RBP,β2-MG,NAG (r=0.863,P<0.001; r=0.777,P<0.001; r=0.374,P=0.002,respectively),while negatively correlated with urine osmolaling,SG (r=-0.519,P<0.001; r=-0.624,P<0.001,respectively). The specificity and sensitivity for renal tubular damage of RBP were 91.03% and 72.06%.
RBP is an idea marker for renal tubular damage,and is useful to diagnose renal tubular damage and assess the extent of the damage.

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Keywords

1 353 healthy people
 
2 groups
 
endogenous creatinine clearance rate
 
idea marker
 
RBP
 
renal biopsy
 
study correlation
 
urinary retinol binding protein
 

Yuncheng Xia