Global Mesothelioma Deaths Reported to the World Health Organization between 1994–2008

Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishiku, Kitakyushu City, Fukuoka Prefecture 807-8555, Japan.
Bulletin of the World Health Organisation (Impact Factor: 5.09). 10/2011; 89(10):716-24, 724A-724C. DOI: 10.2471/BLT.11.086678
Source: PubMed


To carry out a descriptive analysis of mesothelioma deaths reported worldwide between 1994 and 2008.
We extracted data on mesothelioma deaths reported to the World Health Organization mortality database since 1994, when the disease was first recorded. We also sought information from other English-language sources. Crude and age-adjusted mortality rates were calculated and mortality trends were assessed from the annual percentage change in the age-adjusted mortality rate.
In total, 92,253 mesothelioma deaths were reported by 83 countries. Crude and age-adjusted mortality rates were 6.2 and 4.9 per million population, respectively. The age-adjusted mortality rate increased by 5.37% per year and consequently more than doubled during the study period. The mean age at death was 70 years and the male-to-female ratio was 3.6:1. The disease distribution by anatomical site was: pleura, 41.3%; peritoneum, 4.5%; pericardium, 0.3%; and unspecified sites, 43.1%. The geographical distribution of deaths was skewed towards high-income countries: the United States of America reported the highest number, while over 50% of all deaths occurred in Europe. In contrast, less than 12% occurred in middle- and low-income countries. The overall trend in the age-adjusted mortality rate was increasing in Europe and Japan but decreasing in the United States.
The number of mesothelioma deaths reported and the number of countries reporting deaths increased during the study period, probably due to better disease recognition and an increase in incidence. The different time trends observed between countries may be an early indication that the disease burden is slowly shifting towards those that have used asbestos more recently.

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    • "The gender ratio of 1.4 differed substantially from rates of 3.6 of global mesothelioma deaths reported by Delgermaa et al. [11], approaching the ratio of 1.9 obtained in countries within the middle income group. In Korea, where the timing of asbestos consumption is similar to ours, the reported average mesothelioma incidence rate in the period 2001–2010 was 0.83 cases per million with a gender ratio close to 2.0 [23]. "
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    ABSTRACT: There are limited data on mesothelioma mortality in industrializing countries, where, at present, most of the asbestos consumption occurs. To analyze temporal trends and to calculate mortality rates from mesothelioma and cancer of the pleura in Brazil from 2000 to 2012 and to estimate future mortality rates. We retrieved records of deaths from mesothelioma (ICD-10C45) and cancer of the pleura (ICD-10C38.4) from 2000 to 2012 in adults aged 30 years and over. Crude and age-standardized mortality rates (ASMR) were calculated. Rate ratios of mean crude mortality for selected municipalities were compared to the Brazilian rate. A regression was carried out of the annual number of deaths against asbestos consumption using a Generalized Additive Model (GAM). The best model was chosen to estimate the future burden and peak period of deaths. There were 929C45 and 1379 C38.4 deaths. The ratio of men to women for C45 was 1.4. A positive trend in C45 numbers was observed in Brazil (p=0.0012), particularly in São Paulo (p=0.0004) where ASMRs presented an increasing linear trend (p=0.0344). Selected municipalities harboring asbestos manipulation presented 3.7-11 fold rate ratios of C45 compared to Brazil. GAM presented best fits for latencies of 34 years or more. It is estimated that the peak incidence of C45 mortality will occur between 2021 and 2026. The observed ASMRs and the gender ratio close to 1 suggest underreporting. Even so, deaths are increasing and mesothelioma clusters were identified. Compared to industrialized countries Brazil displays a 15-20 year lag in estimated peak mesothelioma mortality which is consistent with the lag of asbestos peak consumption in the country. Copyright © 2015 Elsevier Ltd. All rights reserved.
    08/2015; 39(5). DOI:10.1016/j.canep.2015.08.007
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    • "We assessed the effect on MPM incidence due to the components of age at diagnosis, birth cohort and time period for both genders in the population of a Northern region of Italy. Previous studies based on World Health Statistics Annual on mortality [2] [21] reported that, in Italy, the overall the trend in MPM mortality would have been similar to what observed in other European countries [17] [36]: the incidence rates were always more pronounced among males, the temporal trends correlated with historical asbestos consumptions, and the increment in incidence was explained in most part by an age-cohort effect with a high risk among oldest age-classes and for cohorts born around the years 1940. Our results suggest that the risk of MPM incidence gradually increased among subjects aged 50 or older, among males being three times higher than among females, and reached a peak at the age 74–79. "
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    ABSTRACT: Background: Malignant Mesothelioma (MM) is so associated with (professional, familial or environmental) asbestos exposure that trends in incidence and mortality parallel, after 30-40 years, the trend in asbestos consumption. In recent decades, the industrialized countries have witnessed a steady growth of pleural MM (MPM), following a stabilization or decline in rates in the countries that first adopted restrictive policies. The aim of this study was to evaluate the temporal variations of pleural MM incidence in the Veneto Region of Italy in the period 1987-2010. Methods: We included only MPM with histological or cytological diagnosis. Age-Period-Cohort (APC) models were used to assess the trend in the incidence of MPM in both genders. Future predictions were evaluated by using a Bayesian APC model. Results: In the period 1987-2010, 1600 MPMs have occurred. We observe a positive trend in the incidence in the whole period considered. The APC model showed that in both genders the cohort at higher risk is the one born between the years 1940-1945. Future projections indicate that the trend will decrease after the incidence peak of 2010; yet 1234 men are expected to develop a mesothelioma between 2011 and 2026. Among women, the future MPM rates will be stable or slightly decreasing. Conclusions: The asbestos ban introduced in Italy in the year 1992 as a prospective result will certainly determine a decreasing incidence. However, the extremely long latency of MPM means that its influence is not yet observable.
    Cancer Epidemiology 09/2014; 38(5). DOI:10.1016/j.canep.2014.08.007 · 2.71 Impact Factor
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    • "MM has a prevalence of 1-2 per million per year [8], with 80% of the cases occurring in men [9]. However, the lifetime risk of MM in exposed individuals is 4.5%–10%, which is 40 times higher than that of the average population [10]. Professionals at risk for high levels of exposure include miners, factory and ship workers, carpenters, electricians, boilermakers, insulation manufacturers, and pipe insulators [11]. "
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    Case Reports in Oncological Medicine 10/2013; 2013:570487. DOI:10.1155/2013/570487
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