Article

Reduced iodine load at CT pulmonary angiography with dual-energy monochromatic imaging: comparison with standard CT pulmonary angiography--a prospective randomized trial.

Department of Radiology, St Paul's Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada.
Radiology (impact factor: 5.73). 11/2011; 262(1):290-7. DOI:10.1148/radiol.11110648
Source: PubMed

ABSTRACT To compare quantitative and subjective image quality and radiation dose between standard computed tomographic (CT) pulmonary angiography (CTPA) and CTPA with a dual-energy technique with reduced iodine load.
This prospective study was approved by the institutional review board and each participant provided informed consent. Ninety-four patients (59% male; mean age ± standard deviation, 62 years ± 15) were randomized to one of two protocols: standard CTPA (100-120 kVp) with standard contrast medium injection (n = 46) and dual-energy CTPA (image reconstruction at 50 keV) with the same injection volume as in the standard protocol but composed of contrast medium and saline in a 1:1 fashion, resulting in 50% reduction in iodine load (n = 48). Signal intensity and noise in three central and two segmental pulmonary arteries were measured; signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. A five-point scale was used to subjectively evaluate vascular enhancement and image noise. The proportion of diagnostic (score, ≥ 3) studies and the interreader agreement regarding the dichotomized diagnostic versus nondiagnostic scale were compared between the two groups.
Compared with standard CTPA, dual-energy CTPA demonstrated higher signal intensity in all pulmonary arteries (all P < .01), inferior noise only in segmental arteries (P < .05), higher SNR and CNR (both P < .05), and compatible effective dose (P > .05). The five-point score was higher in the standard CTPA protocol (P < .05). The interreader agreement regarding the dichotomized diagnostic versus nondiagnostic scale was similar (P > .05) between the two groups.
Dual-energy CTPA with image reconstruction at 50 keV allows a significant reduction in iodine load while improving intravascular signal intensity, maintaining SNR and with comparable radiation dose.

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Keywords

50% reduction
 
age ± standard deviation
 
comparable radiation dose
 
compatible effective dose
 
contrast-to-noise ratio
 
dichotomized diagnostic
 
Dual-energy CTPA
 
five-point scale
 
higher signal intensity
 
higher SNR
 
image reconstruction
 
interreader agreement
 
intravascular signal intensity
 
nondiagnostic scale
 
radiation dose
 
Signal intensity
 
signal-to-noise ratio
 
standard computed tomographic
 
standard CTPA
 
subjective image quality