Article

The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis.

Department of Biology Education, Seoul National University, Seoul 151-748, Korea.
Molecules and Cells (impact factor: 2.18). 11/2011; 32(6):549-54. DOI:10.1007/s10059-011-0173-9 pp.549-54
Source: PubMed

ABSTRACT Polycomb group (PcG) proteins maintain the spatial expression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.

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Keywords

caused embryonic segment defects
 
cis-acting silencers
 
embryonic segmentation
 
even-skipped genes
 
genes
 
pair-rule gene mutant patterns
 
PcG proteins
 
pho maternal mutant embryos
 
pho mutant embryos
 
pho mutation
 
Polycomb group
 
PREs
 
repression
 
spatial expression patterns
 
various segmental defects
 
zinc finger DNA binding protein
 

Su-Na Kim