Article

Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents.

Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Nathalal Parekh Marg, Matunga, Mumbai 400019, India.
Bioorganic & medicinal chemistry letters (impact factor: 2.65). 10/2011; 22(1):649-52. DOI:10.1016/j.bmcl.2011.10.064 pp.649-52
Source: PubMed

ABSTRACT A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using molecular hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00μg/ml) against Mycobacteriumtuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC <3.0μg/ml. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene)hydrazinyl) benzothiazole showed MIC of 1.5μg/ml. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs.

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Keywords

4-(aryloxy)benzaldehyde
 
evaluated compounds exhibit MIC <3.0μg/ml. Compound
 
molecular hybridization approach
 
new anti-tubercular drugs
 
potential lead
 
synthesized
 
synthesized compounds exhibited promising activity
 

Vikas N Telvekar