Article

Invasive aspergillosis in children with acquired immunodeficiencies.

Second Department of Pediatrics, Aristotle University, AHEPA Hospital, Thessaloniki, Greece.
Clinical Infectious Diseases (impact factor: 9.15). 11/2011; 54(2):258-67. DOI:10.1093/cid/cir786 pp.258-67
Source: PubMed

ABSTRACT Invasive aspergillosis has emerged as an important cause of morbidity and mortality in immunocompromised children. It remains difficult to diagnose, and outcome depends on early diagnosis, appropriate treatment, and restoration of host defenses. Pediatric patients represent a unique population in their clinical presentation and epidemiology, particularly in respect to the utility of newer diagnostic tools and the pharmacokinetics of antifungal agents. This article reviews the presentation and epidemiology of invasive aspergillosis in children and adolescents with acquired immunodeficiencies and discusses the value of current diagnostic tools and the options for treatment and prevention in this population.

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Keywords

antifungal agents
 
appropriate treatment
 
article reviews
 
clinical presentation
 
current diagnostic tools
 
diagnose
 
discusses
 
host defenses
 
Invasive aspergillosis
 
morbidity
 
newer diagnostic tools
 
Pediatric patients
 
pharmacokinetics
 
unique population