On the association between soft drink consumption and Helicobacter pylori infection.
ABSTRACT The association between soft drink (SD) consumption and Helicobacter pylori infection remains unclear.
To examine the relationship between SD consumption and H. pylori infection.
A prospective study included individuals who were referred for an upper gastrointestinal endoscopic examination because chronic dyspepsia within a period of 1 year. In addition to determining daily SD consumption and the risk factors for H. pylori infection by asking all study participants to complete a standard questionnaire about their diet, daily eating and drinking habits, and their lifestyle before undergoing the endoscopic examination. H. pylori infection was established by a positive result of the rapid urease test and histology.
Of the 312 individuals who were referred for the endoscopic examination because chronic dyspepsia, 269 met the inclusion criteria. H. pylori infection was found in 164 (61%) of the 269 study participants, and, of these, 104/164 individuals were SD consumers with H. pylori infection versus 24/105 individuals without H. pylori infection (63 vs. 23%, respectively, P < 0.001). The results of the multiple logistic regression analysis showed that SD consumption (odds ratio = 4.0; 95% confidence interval = 3.19-5.82, P < 0.001), was associated with H. pylori infection.
SD consumption is associated with H. pylori infection in individuals with chronic dyspepsia.
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ABSTRACT: Despite the widespread prevalence and serious clinical sequelae of infection with Helicobacter pylori, there have been few large population-based studies, using randomly selected subjects, examining the epidemiology of this infection. To examine the distribution and determinants of H. pylori infection in a developed country. Overall 4742 subjects, aged 12-64, from Northern Ireland were randomly selected. Helicobacter pylori specific IgG antibodies were measured by enzyme linked immunosorbent assay, using an acid-glycine extract antigen, in stored serum from subjects who had participated in three linked population-based surveys of cardiovascular risk factors performed in 1986 and 1987. The overall prevalence of H. pylori infection was 50.5%. Prevalence increased with age from 23.4% in 12-14 year olds to 72.7% in 60-64 year olds: chi 2 for trend 518, P < 10(-4). In subjects aged > or = 25, infection was more common in males (60.9%) than females (55.2%): chi 2 = 9.53, P < 0.01. This relation remained significant after adjusting for age, and measures of socioeconomic class: odds ratio (OR) for infection, male versus female was 1.19 (95% confidence interval [CI]: 1.02-1.40). Infection was associated with social class: the adjusted OR of infection in subjects from manual social classes relative to those from non-manual classes was 1.7 (95% CI: 1.47-1.98). Infection was significantly more common in current smokers and ex-smokers than in subjects who had never smoked: adjusted OR for infection, ex-smokers versus never smoked was 1.22 (95% CI: 1.01-1.49); for smokers of > or = 20/day versus never smoked OR = 1.33 (95% CI: 1.05-1.67). Infection was not associated with height in adult males but mean height in infected women was lower than in uninfected women after adjusting for age and socioeconomic status: difference in mean height (SE), -0.85 cm (0.32), P < 0.01. There was no demonstrable relationship between H. pylori infection and current alcohol intake. This study demonstrated a high prevalence of infection in a population from a developed country. Previously reported associations between H. pylori infection, age, sex, social class, and reduced height in females were confirmed and smoking was identified as a possible risk factor for H. pylori infection.International Journal of Epidemiology 08/1997; 26(4):880-7. · 6.98 Impact Factor
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ABSTRACT: Intraluminal duodenal pH was recorded using a combined miniature electrode and logged digitally every 10 or 20 seconds for five hours (basal/meal/drink) in eight control subjects and 11 patients with duodenal ulcer (five on and off treatment with cimetidine). Over the whole test there were no significant differences in duodenal mean pH or log mean hydrogen ion activity (LMHa) between control subjects and patients with duodenal ulcer, but there were significantly longer periods of duodenal acidification (pH less than 4) and paradoxically more periods of duodenal alkalinisation (pH greater than 6) in the duodenal ulcer group compared with controls. After a meal duodenal mean pH and LMHa fell significantly in both controls and patients with duodenal ulcer, with more periods of duodenal acidification and alkalinisation in the duodenal ulcer group. An exogenous acid load (Coca-Cola) significantly increased the periods of duodenal acidification, and reduced alkalinisation, in both groups. Cimetidine significantly increased mean pH and LMHa and abolished the brief spikes of acidification in four of five patients with duodenal ulcer. Peak acid output (but not basal acid output) was significantly correlated with duodenal mean pH and LMHa but not with the periods of duodenal acidification. Smoking did not affect duodenal pH in either group.Gut 05/1984; 25(4):386-92. · 10.73 Impact Factor
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ABSTRACT: To investigate the effect of alcohol consumption on the risk of Helicobacter pylori infection, standardized questionnaires on drinking habits were used to interview 451 patients, whose H. pylori status was determined both by culture and serology. Reported alcohol consumption did not increase the risk of H. pylori infection (a 1.0 odds ratio, CI95 0.6-1.6). However, when the patients were divided into two age-groups, those under 35 years who reported to use alcohol seemed to have a slightly higher risk of H. pylori infection (a 3.3 odds ratio CI95 0.9-12.2) compared to those over 35 years (a 1.0 odds ratio, CI95 0.5-2.2). This phenomenon did not reach statistical significance. The type of alcohol consumed did not affect the age-adjusted risk of H. pylori infection. If pathologically defined chronic gastritis was found, the risk for H. pylori was high (a 26.7 odds ratio, CI95 12.1-59.0, for those under 35 years, and a 12.8 odds ratio, CI95 6.7-24.3, for those over 35 years of age.Digestion 02/1991; 50(2):92-8. · 1.94 Impact Factor