Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.
Cell metabolism (Impact Factor: 17.57). 11/2011; 14(5):612-22. DOI: 10.1016/j.cmet.2011.10.002
Source: PubMed

ABSTRACT Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.

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Available from: Sander Kersten, Sep 28, 2015
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    • "A considerable amount of data has accumulated on treating humans with STACs (Hubbard & Sinclair, 2014). Resveratrol has had mixed efficacy, in that its insulin-sensitizing effects (Ghanim et al., 2011; Smoliga et al., 2011) and DR-like phenotypes have been observed in elderly and obese humans (Timmers et al., 2011), but not in nonobese subjects with normal glucose tolerance (Yoshino et al., 2012). This suggests that STACs may restore homeostasis preferentially in metabolically compromised individuals. "
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    • "et al . , 2006 ; Barger et al . , 2008 ; Pearson et al . , 2008 ; Rivera et al . , 2009 ; Rocha et al . , 2009 ) . While the resveratrol effects are intensively studied in animal models only few clinical trials were conducted so far to study the effects of resveratrol supplementation in the con - text of human obesity and coronary artery disease ( Timmers et al . , 2011 ; Tome - Carneiro et al . , 2013b ) , yet there exists some controversy ( Poulsen et al . , 2013 ) and the effect of resveratrol on the expression of inflammatory cytokines , in particular IL - 6 , IL - 8 , and MCP - 1 in obesity remains to be further investigated . Therefore it was the aim of this study to investigate the effects of re"
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    ABSTRACT: Obesity is associated with an inflammatory status and linked with a number of pathophysiological complications among them cardiovascular disease, type 2 diabetes mellitus, or the metabolic syndrome. Resveratrol was proposed to improve obesity-related inflammatory problems, but the effect of resveratrol on cytokine expression in obesity is not completely understood. In this study, we used an in vitro model of human adipose tissue inflammation to examine the effects of resveratrol on the production of the inflammatory cytokines IL-6, IL-8, and MCP-1. We found that resveratrol reduced IL-6, IL-8, and MCP-1 levels in a concentration-dependent manner in adipocytes under inflammatory conditions. Further experiments showed that the action of resveratrol was mainly due to its NFkB inhibitory potential. Thus, our data support the concept that resveratrol can alleviate obesity-induced up-regulation of inflammatory cytokines providing a new insight towards novel treatment options in obesity.
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    • "During resveratrol treatment the muscles of the subjects exhibited increased levels of activated AMPK, SIRT1 and PGC-1α as well as decreased inflammation markers (Timmers et al., 2011). "
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