Article

Gene therapy for lung neoplasms.

Division of Pulmonary, Allergy & Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Clinics in chest medicine (Impact Factor: 2.17). 12/2011; 32(4):865-85. DOI: 10.1016/j.ccm.2011.08.006
Source: PubMed

ABSTRACT Both advanced-stage lung cancer and malignant pleural mesothelioma are associated with a poor prognosis. Advances in treatment regimens for both diseases have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in several clinical trials. Strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination approaches, and adoptive transfer of modified immune cells. This review considers the clinical results, limitations, and future directions of gene therapy trials for thoracic malignancies.

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Available from: Elliot Wakeam, Apr 07, 2014
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