Article

Isoflurane anesthesia preserves liver and lung mitochondrial oxidative capacity after gut ischemia-reperfusion.

Pôle Anesthésie Réanimation Chirurgicale, SAMU, Hôpitaux Universitaires de Strasbourg, Avenue Molière, 67098 Strasbourg, France.
Anesthesia and analgesia (impact factor: 3.08). 11/2011; 113(6):1438-41. DOI:10.1213/ANE.0b013e3182367a10 pp.1438-41
Source: PubMed

ABSTRACT Lung and liver dysfunction is involved in gut ischemia-reperfusion (IR)-induced multiple organ failure. We compared the effects of ketamine and isoflurane on liver and lung mitochondrial oxidative capacity after gut IR.
Adult male Wistar rats were randomized into 4 groups (controls and gut IR receiving either intraperitoneal ketamine or inhaled isoflurane). Maximal oxygen consumption and the activity of respiratory chain complexes were measured on isolated liver and lung mitochondria.
Gut IR significantly impaired liver and lung mitochondrial oxidative capacity when using ketamine but not isoflurane.
Isoflurane preserved liver and lung mitochondrial oxidative capacity after gut IR.

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Keywords

4 groups
 
Adult male Wistar rats
 
Gut IR
 
gut ischemia-reperfusion
 
inhaled isoflurane
 
intraperitoneal ketamine
 
IR)-induced multiple organ failure
 
isoflurane
 
liver dysfunction
 
lung mitochondria
 
lung mitochondrial oxidative capacity
 
Maximal oxygen consumption
 
respiratory chain complexes