Isoflurane Anesthesia Preserves Liver and Lung Mitochondrial Oxidative Capacity After Gut Ischemia-Reperfusion

Pôle Anesthésie Réanimation Chirurgicale, SAMU, Hôpitaux Universitaires de Strasbourg, Avenue Molière, 67098 Strasbourg, France.
Anesthesia and analgesia (Impact Factor: 3.47). 11/2011; 113(6):1438-41. DOI: 10.1213/ANE.0b013e3182367a10
Source: PubMed

ABSTRACT Lung and liver dysfunction is involved in gut ischemia-reperfusion (IR)-induced multiple organ failure. We compared the effects of ketamine and isoflurane on liver and lung mitochondrial oxidative capacity after gut IR.
Adult male Wistar rats were randomized into 4 groups (controls and gut IR receiving either intraperitoneal ketamine or inhaled isoflurane). Maximal oxygen consumption and the activity of respiratory chain complexes were measured on isolated liver and lung mitochondria.
Gut IR significantly impaired liver and lung mitochondrial oxidative capacity when using ketamine but not isoflurane.
Isoflurane preserved liver and lung mitochondrial oxidative capacity after gut IR.

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