In vitro antileishmanial and antitrypanosomal activities of five medicinal plants from Burkina Faso

Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192, Ouagadougou 03, Burkina Faso.
Parasitology Research (Impact Factor: 2.1). 10/2011; 110(5):1779-83. DOI: 10.1007/s00436-011-2699-3
Source: PubMed


After ethnobotanical surveys in central and western regions of Burkina Faso, five plants namely Lantana ukambensis (Verbenaceae), Xeoderris sthulmannii (Fabaceae), Parinari curatellifollia (Chrysobalanaceae), Ozoroa insignis (Anacardiaceae), and Ficus platyphylla (Moraceae) were selected for their traditional use in the treatment of parasitic diseases and cancer. Our previous studies have focused on the phytochemical, genotoxicity, antioxidant, and antiproliferative activities of these plants. In this study, the methanol extract of each plant was tested to reveal probable antileishmanial and antitrypanosomal activities. Colorimetric and spectrophotometric methods were used for the detection of antileishmanial and antitrypanosomal activities. Leishmania donovani (LV9 WT) and Trypanosoma brucei brucei GVR 35 were used to test the antileishmanial and antitrypanosomal activities, respectively. All extracts of tested plants showed a significant antitrypanosomal activity with minimum lethal concentrations between 1.5 and 25 μg/ml, the L. ukambensis extract being the most active. In the antileishmanial test, only the extract from L. ukambensis showed significant activity with an inhibitory concentration (IC(50)) of 6.9 μg/ml. The results of this study contribute to the promotion of traditional medicine products and are preliminary for the isolation of new natural molecules for the treatment of leishmaniasis and trypanosomiasis.

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    • "HAT control is seriously hindered because only a few drugs are available, all of which have significant drawbacks including mandatory parenteral administration, unaffordability, and unacceptable toxicity. Only a handful of drugs—melarsoprol, nifurtimox, and eflornithine (see Figure 4)—are efficacious against cerebral stage 2 disease occurring in the West African type of sleeping sickness [3,77,84]. Drug resistance, especially after melarsoprol treatment reported in several African countries (DR Congo, Sudan, Uganda, and Angola), represents a growing challenge to the control of African trypanosomiasis [3,85]. Enormous efforts are being invested to improve the use of currently registered drugs, including a shortened ten-day course (rather than 21–35 days) of melarsoprol that followed pharmacokinetic studies and a clinical trial with a three-day course of pentamidine. "
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    ABSTRACT: Vector-borne protozoan diseases represent a serious public health challenge, especially in the tropics where poverty together with vector-favorable climates are the aggravating factors. Each of the various strategies currently employed to face these scourges is seriously inadequate. Despite enormous efforts, vaccines--which represent the ideal weapon against these parasitic diseases--are yet to be sufficiently developed and implemented. Chemotherapy and vector control are therefore the sole effective attempts to minimize the disease burden. Nowadays, both strategies are also highly challenged by the phenomenon of drug resistance, which affects virtually all drug regiments currently used. The recently growing support from international organizations and governments of some endemic countries is warmly welcome, and should be optimally exploited in the various approaches to drug research and development to overcome the burden of these prevalent diseases, especially malaria, leishmaniasis, Human African Trypanosomiasis (HAT), and Chagas disease.
    Infectious Diseases of Poverty 01/2014; 3(1):1. DOI:10.1186/2049-9957-3-1 · 4.11 Impact Factor
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    • "(Combretaceae) is a sub- Saharan African tree with bark and leaves that are used traditionally as an anti-malarial remedy. Several recent studies have confirmed these effects in vitro on different Plasmodium falciparum , Leishmania donovani and Trypanosoma brucei strains (Vonthron-Senecheau et al., 2003; Shuaibu et al., 2008a, 2008b; Gansane et al., 2010; Attioua et al., 2011; Akanbi et al., 2012; Sawadogo et al., 2012). In European countries, the ethanol-soluble fraction of the bark of Anogeissus leiocarpus has found applications in the cosmetic industry as a skin protective ingredient (Bonte and Saunois, 2002; Corstjens et al., 2011). "
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    Phytochemical Analysis 07/2013; 24(4). DOI:10.1002/pca.2418 · 2.34 Impact Factor
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    • "Plectronialeucantha Krause) (Joanne et al., 2011) have both shown the presence of ursolic acid. Perhaps, that is the reason why both exhibit antileishmanial activity.Furthermore, the report that the antileishmanial activity of Lantana ukambensis could be due to the presence of polyphenols, triterpenes, and saponins (Sawadogo et al., 2012), is in line with other results that diterpenoidsand triterpenoids (Tan et al., 2002), saponins (Ridoux et al., 2001), and polyphenols (Kolodziej, 2001) are phytochemical compounds with antileishmanial effect. "
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    ABSTRACT: Leishmaniasis is a disease caused by the protozoan parasites which belong to the genus Leishmania. Some known species of Leishmania include L. tropica, L. donovani, L. mexicana, L. aethiopica, L. Infantum, L. donovani, L. mexicana, L. braziliensis, L. chagasi and L. amazonensis. Leishmaniasis is transmitted through the bite of phlebotomine sandflies. The existence of Leishmaniasis has been recorded in several countries in the Mediterranean, Central and South America, Asia, Africa, the Middle East, China, India and the Caribbean. Chemotherapy and vector control are the known available means of combating the Leishmaniasis as the development of effective vaccines are still under way. Crude solvent extracts and isolated compounds from certain plants have however, shown significant activity against leishmanial parasite. Some of the plants reported to have antileishmanial activity include Tridax procumbens, Urechites andrieuxii Muell.-Arg. (Apocynaceae), Desmodium gangeticum, Pseudelephantopus spicatus, Himatanthus sucuuba, among others. Of the antileishmanial plants, the greatest number belonged to the Apocynaceae. The antileishmanial activity of the plants reported in this piece of work suggests that these plants can be used to treat Leishmaniasis. The level of activity exhibited by the crude solvent extracts or the isolated constituent(s) depends on largely on the type of solvent used for the extraction and also on the plant part used.
    Asian Journal of Scientific Research 03/2013; 3(2):157-173.
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