Relationship between Bispectral Index Values and Volatile Anesthetic Concentrations during the Maintenance Phase of Anesthesia in the B-Unaware Trial

Division of Cardiothoracic Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Anesthesiology (Impact Factor: 5.88). 12/2011; 115(6):1209-18. DOI: 10.1097/ALN.0b013e3182395dcb
Source: PubMed

ABSTRACT Hypnotic depth during anesthesia affects electroencephalography waveforms and electroencephalogram-derived indices, such as the bispectral index (BIS). Titrating anesthetic administration against the BIS assumes reliable relationships between BIS values, electroencephalogram waveforms, and effect site concentration, beyond loss of responsiveness. Associations among BIS, end-tidal anesthetic concentrations (ETAC), and patient characteristics were examined during anesthetic maintenance, using B-Unaware trial data.
Pharmacokinetically stable ETAC epochs during intraoperative anesthetic maintenance were analyzed. A generalized estimating equation determined independent relationships among BIS, ETAC (in age-adjusted minimum alveolar concentration equivalents), patient characteristics, and 1-yr mortality. Further individual and population characteristics were explored graphically.
A total of 3,347,523 data points from 1,100 patients were analyzed over an ETAC range from 0.42 to 1.51 age-adjusted minimum alveolar concentration. A generalized estimating equation yielded a best predictive equation: BIS = 62.9-1.6 (if age younger than 60 yr) -1.6 (if female) -2.5 (if American Society of Anesthesiologists physical status more than 3) -2.6 (if deceased at 1 yr) -2.5 (if N2O was not used) -1.4 (if midazolam dose more than 2 mg) -1.3 (if opioid dose more than 50 morphine equivalents) -15.4 × age-adjusted minimum alveolar concentration. Although a population relationship between ETAC and BIS was apparent, interindividual variability in the strength and reliability of this relationship was large. Decreases in BIS with increasing ETAC were not reliably observed. Individual-patient linear regression yielded a median slope of -8 BIS/1 age-adjusted minimum alveolar concentration (interquartile range -30, 0) and a median correlation coefficient of -0.16 (interquartile range -0.031, -0.50).
Independent of pharmacokinetic confounding, BIS frequently correlates poorly with ETAC, is often insensitive to clinically significant changes in ETAC, and is vulnerable to interindividual variability. BIS is therefore incapable of finely guiding volatile anesthetic titration during anesthetic maintenance.

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    • "Over the past several decades, various anesthesia monitors have been introduced into clinical practice and employed different electroencephalogram (EEG) indices as a means to assess the depth of anesthesia, such as bispectral analysis (BIS), auditory-evoked potential (AEP), cerebral state index (CSI) and spectral entropy. However, these anesthesia monitoring systems are sometimes inadequate in preventing perioperative awakening (Whitlock et al., 2011; Zanner et al., 2009; Pilge et al., 2006; Fritz et al., 2013; Avidan et al., 2011; Rehberg et al., 2008; Mashour et al., 2011). One possible reason for their insufficiencies is the time delay that inevitably occurs when calculating anesthesia depth. "
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    Clinical Neurophysiology 06/2014; 126(2). DOI:10.1016/j.clinph.2014.04.019 · 3.10 Impact Factor
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    • "Other trials, however, failed to show benefit of processed EEG-guided anesthesia. In a large trial of 1,100 patients and over 3.3 million data points, processed EEG failed to correlate with end-tidal anesthetic concentration and was insensitive to changes in end-tidal anesthetic concentration.61 Another large-scale prospective study of over 6,000 subjects comparing processed EEG-guided protocols and end-tidal anesthetic concentration-guided protocols for maintenance of anesthesia found no difference in the amount of anesthesia used or the rate of awareness between the groups.62 "
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    Medical Devices: Evidence and Research 03/2014; 7(1):45-53. DOI:10.2147/MDER.S43428
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    • "These monitors do not measure signs of consciousness but instead a pharmacodynamic effect of anesthetic drugs on the spontaneous EEG. Even worse, their ability to help titrating anesthetic drugs during general anesthesia has been questioned recently [25]. We therefore propose a completely new paradigm to detect intraoperative awareness, based on movement-related BCIs. "
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    PLoS ONE 09/2012; 7(9):e44336. DOI:10.1371/journal.pone.0044336 · 3.23 Impact Factor
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