Article

RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101-6189, USA.
Biochemical and Biophysical Research Communications (impact factor: 2.48). 11/2011; 415(2):215-9. DOI:10.1016/j.bbrc.2011.10.063 pp.215-9
Source: PubMed

ABSTRACT Heterotrimeric G proteins have a critical role in mediating signal transduction by ligand-stimulated GPCRs. While activation of heterotrimeric G proteins is known to proceed via the G protein guanine nucleotide cycle, there is much uncertainty regarding the process that determines efficacy, the extent of response across signaling pathways. Gα(GTP) can interact with multiple binding partners, including several effectors and regulators. Cross-talk by other receptor-signaling pathways can alter the response. It remains unclear whether G protein efficacy is regulated. This lack of clarity impairs our ability to predict and manipulate the pharmacological behavior of activated G proteins. This review will discuss emerging evidence that implicates monomeric RhoA in the process that regulates G(q) efficacy.

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Keywords

activated G proteins
 
clarity impairs
 
critical role
 
Cross-talk
 
determines efficacy
 
G protein efficacy
 
G protein guanine nucleotide cycle
 
Heterotrimeric G proteins
 
implicates monomeric RhoA
 
ligand-stimulated GPCRs
 
manipulate
 
mediating signal transduction
 
multiple binding partners
 
pharmacological behavior
 
receptor-signaling pathways
 
regulates G(q)
 
regulators
 
signaling pathways
 

Irene Litosch