Mitotic Exit Control: A Space and Time Odyssey

Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
Current biology: CB (Impact Factor: 9.92). 10/2011; 21(20):R857-9. DOI: 10.1016/j.cub.2011.09.023
Source: PubMed

ABSTRACT The mitotic exit network (MEN), a protein kinase cascade under the switch-like control of the small GTPase Tem1, triggers exit from mitosis in budding yeast. Now it emerges that signals from both Tem1 and the yeast Polo kinase Cdc5 converge onto the MEN kinase Cdc15 to accurately restrict MEN activation to late mitosis.

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